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A phase IIb, open-label, randomized controlled dose ranging multi-centre trial to evaluate the safety, tolerability, pharmacokinetics and exposure-response relationship of different doses of delpazolid in combination with bedaquiline delamanid moxifloxacin in adult subjects with newly diagnosed, uncomplicated, smear-positive, drug-sensitive pulmonary tuberculosis.
Dierig A, Hoelscher M, Schultz S, Hoffmann L, Jarchow-MacDonald A, Svensson EM, Te Brake L, Aarnoutse R, Boeree M, McHugh TD, Wildner LM, Gong X, Phillips P, Minja LT, Ntinginya N, Mpagama S, Liyoyo A, Wallis RS, Sebe M, Mhimbira FA, Mbeya B, Rassool M, Geiter L, Cho YL, Heinrich N. Dierig A, et al. Among authors: hoelscher m. Trials. 2023 Jun 6;24(1):382. doi: 10.1186/s13063-023-07354-5. Trials. 2023. PMID: 37280643 Free PMC article. Clinical Trial.
Effect of seven anti-tuberculosis treatment regimens on sputum microbiome: a retrospective analysis of the HIGHRIF study 2 and PanACEA MAMS-TB clinical trials.
Musisi E, Wyness A, Eldirdiri S, Dombay E, Mtafya B, Ntinginya NE, Heinrich N, Kibiki GS, Hoelscher M, Boeree M, Aarnoutse R, Gillespie SH, Sabiiti W; PanACEA consortium. Musisi E, et al. Among authors: hoelscher m. Lancet Microbe. 2023 Nov;4(11):e913-e922. doi: 10.1016/S2666-5247(23)00191-X. Epub 2023 Oct 10. Lancet Microbe. 2023. PMID: 37832571 Free article.
Performance of spirometry assessment at TB diagnosis.
Rachow A, Ivanova O, Bakuli A, Khosa C, Nhassengo P, Owolabi O, Jayasooriya S, Ntinginya NE, Sabi I, Rassool M, Bennet J, Niemann S, Mekota AM, Allwood BW, Wallis RS, Charalambous S, Hoelscher M, Churchyard G. Rachow A, et al. Among authors: hoelscher m. Int J Tuberc Lung Dis. 2023 Aug 1;27(11):850-857. doi: 10.5588/ijtld.23.0040. Int J Tuberc Lung Dis. 2023. PMID: 37880896 Free PMC article.
Lung outcomes and related risk factors in patients after SARS-CoV-2 infection: a hospitalised single-centre cohort from Johannesburg, South Africa.
Glover NA, Ivanova O, Sathar F, Riess F, Shambhu RR, Mekota AM, Zurba L, Menezes C, Alexandra van Blydenstein S, Kalla I, Hoelscher M, Saathoff E, Charalambous S, Rachow A. Glover NA, et al. Among authors: hoelscher m. EClinicalMedicine. 2024 Apr 11;71:102588. doi: 10.1016/j.eclinm.2024.102588. eCollection 2024 May. EClinicalMedicine. 2024. PMID: 38623400 Free PMC article.
Reflex Xpert MTB/XDR Testing of Residual Rifampicin-Resistant Specimens: A Clinical Laboratory-Based Diagnostic Accuracy and Feasibility Study in South Africa.
Centner CM, Munir R, Tagliani E, Rieß F, Brown P, Hayes C, Dolby T, Zemanay W, Cirillo DM, David A, Schumacher SG, Denkinger CM, Ruhwald M, Leukes VN, Nicol MP, Van der Walt I, Kisten G, Gumede M, Mace A, Brink A, Stevens W, Scott L, Penn-Nicholson A, Cox H; TB-CAPT Consortium. Centner CM, et al. Open Forum Infect Dis. 2024 Jul 31;11(8):ofae437. doi: 10.1093/ofid/ofae437. eCollection 2024 Aug. Open Forum Infect Dis. 2024. PMID: 39165581 Free PMC article.
New admissions and asymptomatic TB cases seem to fuel TB epidemic in prisons, a cross sectional survey in Tanzania.
Mangu CD, Clowes P, van den Hombergh J, Mwakabenga C, Mwanyonga S, Ambindwile J, Kayombo F, Minja M, Kalluvya S, Gerwing-Adima L, Kasang C, Mueller A, Chilolo E, Angolwisye J, Nsajigwa D, Kachima A, Kamala D, Mutayobya B, Ntinginya NE, Hoelscher M, Saathoff E, Rachow A. Mangu CD, et al. Among authors: hoelscher m. PLOS Glob Public Health. 2024 Oct 14;4(10):e0002372. doi: 10.1371/journal.pgph.0002372. eCollection 2024. PLOS Glob Public Health. 2024. PMID: 39401196 Free PMC article.
Investigating the treatment shortening potential of a combination of bedaquiline, delamanid and moxifloxacin with and without sutezolid, in a murine tuberculosis model with confirmed drug exposures.
Walter K, Te Brake LHM, Lemm AK, Hoelscher M, Svensson EM, Hölscher C, Heinrich N. Walter K, et al. Among authors: hoelscher m. J Antimicrob Chemother. 2024 Oct 1;79(10):2607-2610. doi: 10.1093/jac/dkae266. J Antimicrob Chemother. 2024. PMID: 39110473 Free PMC article.
331 results