Zuo E - Search Results

1

Author Correction: Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation.

Li G, Dong X, Luo J, Yuan T, Li T, Zhao G, Zhang H, Zhou J, Zeng Z, Cui S, Wang H, Wang Y, Yu Y, Yuan Y, Zuo E, Xu C, Huang J, Zhou Y. Li G, et al. Among authors: zuo e. Nat Commun. 2024 Oct 18;15(1):9001. doi: 10.1038/s41467-024-53171-y. Nat Commun. 2024. PMID: 39424826 Free PMC article. No abstract available.

2

Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos.

Zuo E, Sun Y, Wei W, Yuan T, Ying W, Sun H, Yuan L, Steinmetz LM, Li Y, Yang H. Zuo E, et al. Science. 2019 Apr 19;364(6437):289-292. doi: 10.1126/science.aav9973. Epub 2019 Feb 28. Science. 2019. PMID: 30819928 Free PMC article.

3

A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects.

Zuo E, Sun Y, Yuan T, He B, Zhou C, Ying W, Liu J, Wei W, Zeng R, Li Y, Yang H. Zuo E, et al. Nat Methods. 2020 Jun;17(6):600-604. doi: 10.1038/s41592-020-0832-x. Epub 2020 May 18. Nat Methods. 2020. PMID: 32424272

4

GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos.

Zuo E, Sun Y, Wei W, Yuan T, Ying W, Sun H, Yuan L, Steinmetz LM, Li Y, Yang H. Zuo E, et al. Nat Protoc. 2020 Sep;15(9):3009-3029. doi: 10.1038/s41596-020-0361-1. Epub 2020 Aug 14. Nat Protoc. 2020. PMID: 32796939 Free PMC article.

5

Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects.

Lee S, Ding N, Sun Y, Yuan T, Li J, Yuan Q, Liu L, Yang J, Wang Q, Kolomeisky AB, Hilton IB, Zuo E, Gao X. Lee S, et al. Among authors: zuo e. Sci Adv. 2020 Jul 15;6(29):eaba1773. doi: 10.1126/sciadv.aba1773. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32832622 Free PMC article.

6

Optimization of C-to-G base editors with sequence context preference predictable by machine learning methods.

Yuan T, Yan N, Fei T, Zheng J, Meng J, Li N, Liu J, Zhang H, Xie L, Ying W, Li D, Shi L, Sun Y, Li Y, Li Y, Sun Y, Zuo E. Yuan T, et al. Among authors: zuo e. Nat Commun. 2021 Aug 12;12(1):4902. doi: 10.1038/s41467-021-25217-y. Nat Commun. 2021. PMID: 34385461 Free PMC article.

7

Human cleaving embryos enable efficient mitochondrial base-editing with DdCBE.

Wei Y, Xu C, Feng H, Xu K, Li Z, Hu J, Zhou L, Wei Y, Zuo Z, Zuo E, Li W, Yang H, Zhang M. Wei Y, et al. Among authors: zuo z, zuo e. Cell Discov. 2022 Feb 1;8(1):7. doi: 10.1038/s41421-021-00372-0. Cell Discov. 2022. PMID: 35102133 Free PMC article. No abstract available.

8

Mitochondrial base editor DdCBE causes substantial DNA off-target editing in nuclear genome of embryos.

Wei Y, Li Z, Xu K, Feng H, Xie L, Li D, Zuo Z, Zhang M, Xu C, Yang H, Zuo E. Wei Y, et al. Among authors: zuo z, zuo e. Cell Discov. 2022 Mar 18;8(1):27. doi: 10.1038/s41421-022-00391-5. Cell Discov. 2022. PMID: 35304438 Free PMC article. No abstract available.

9

Mini-dCas13X-mediated RNA editing restores dystrophin expression in a humanized mouse model of Duchenne muscular dystrophy.

Li G, Jin M, Li Z, Xiao Q, Lin J, Yang D, Liu Y, Wang X, Xie L, Ying W, Wang H, Zuo E, Shi L, Wang N, Chen W, Xu C, Yang H. Li G, et al. Among authors: zuo e. J Clin Invest. 2023 Feb 1;133(3):e162809. doi: 10.1172/JCI162809. J Clin Invest. 2023. PMID: 36512423 Free PMC article.

10

Cytosine base editors induce off-target mutations and adverse phenotypic effects in transgenic mice.

Yan N, Feng H, Sun Y, Xin Y, Zhang H, Lu H, Zheng J, He C, Zuo Z, Yuan T, Li N, Xie L, Wei W, Sun Y, Zuo E. Yan N, et al. Among authors: zuo z, zuo e. Nat Commun. 2023 Mar 30;14(1):1784. doi: 10.1038/s41467-023-37508-7. Nat Commun. 2023. PMID: 36997536 Free PMC article.

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