Yan XX - Search Results

1

Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer's disease.

Zhang Y, Chen X, Chen L, Shao M, Zhu W, Xing T, Guo T, Jia Q, Yang H, Yin P, Yan XX, Yu J, Li S, Li XJ, Yang S. Zhang Y, et al. Among authors: yan xx. Mol Neurodegener. 2024 Oct 18;19(1):75. doi: 10.1186/s13024-024-00771-3. Mol Neurodegener. 2024. PMID: 39425207 Free PMC article.

2

β₂-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer's disease model mice.

Zhao Y, Zheng Q, Hong Y, Gao Y, Hu J, Lang M, Zhang H, Zhou Y, Luo H, Zhang X, Sun H, Yan XX, Huang TY, Wang YJ, Xu H, Liu C, Wang X. Zhao Y, et al. Among authors: yan xx. Nat Neurosci. 2023 Jul;26(7):1170-1184. doi: 10.1038/s41593-023-01352-1. Epub 2023 Jun 1. Nat Neurosci. 2023. PMID: 37264159

3

Synthesis and Bioevaluation of 2-Styrylquinoxaline Derivatives as Tau-PET Tracers.

Wu N, Zhang L, Zhang X, Zhang Q, Liu J, Li Y, Yan XX, Liang Y, Zhang J, Cui M. Wu N, et al. Among authors: yan xx. Mol Pharm. 2023 Nov 6;20(11):5865-5876. doi: 10.1021/acs.molpharmaceut.3c00717. Epub 2023 Oct 18. Mol Pharm. 2023. PMID: 37852240

4

TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington's disease.

Qin Y, Chen L, Zhu W, Song J, Lin J, Li Y, Zhang J, Song X, Xing T, Guo T, Duan X, Zhang Y, Ruan E, Wang Q, Li B, Yang W, Yin P, Yan XX, Li S, Li XJ, Yang S. Qin Y, et al. Among authors: yan xx. Sci Adv. 2024 May 17;10(20):eadl2036. doi: 10.1126/sciadv.adl2036. Epub 2024 May 17. Sci Adv. 2024. PMID: 38758800 Free PMC article.

5

Suppressing UBE2N ameliorates Alzheimer's disease pathology through the clearance of amyloid beta.

Zhang C, Jia Q, Zhu L, Hou J, Wang X, Li D, Zhang J, Zhang Y, Yang S, Tu Z, Yan XX, Yang W, Li S, Li XJ, Yin P. Zhang C, et al. Among authors: yan xx. Alzheimers Dement. 2024 Sep;20(9):6287-6304. doi: 10.1002/alz.14122. Epub 2024 Jul 17. Alzheimers Dement. 2024. PMID: 39015037 Free PMC article.

6

Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models.

Han R, Wang Q, Xiong X, Chen X, Tu Z, Li B, Zhang F, Chen C, Pan M, Xu T, Chen L, Wang Z, Liu Y, He D, Guo X, He F, Wu P, Yin P, Liu Y, Yan X, Li S, Li XJ, Yang W. Han R, et al. J Clin Invest. 2024 Oct 15;134(20):e179633. doi: 10.1172/JCI179633. J Clin Invest. 2024. PMID: 39403921 Free PMC article.

7

TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration.

Zhong L, Sheng X, Wang W, Li Y, Zhuo R, Wang K, Zhang L, Hu DD, Hong Y, Chen L, Rao H, Li T, Chen M, Lin Z, Zhang YW, Wang X, Yan XX, Chen X, Bu G, Chen XF. Zhong L, et al. Among authors: yan xx. Immunity. 2023 Aug 8;56(8):1794-1808.e8. doi: 10.1016/j.immuni.2023.06.016. Epub 2023 Jul 12. Immunity. 2023. PMID: 37442133 Free article.

8

Bridging integrator 1 fragment accelerates tau aggregation and propagation by enhancing clathrin-mediated endocytosis in mice.

Zhang X, Zou L, Tang L, Xiong M, Yan XX, Meng L, Chen G, Xiong J, Nie S, Zhang Z, Chen Q, Zhang Z. Zhang X, et al. Among authors: yan xx. PLoS Biol. 2024 Jan 11;22(1):e3002470. doi: 10.1371/journal.pbio.3002470. eCollection 2024 Jan. PLoS Biol. 2024. PMID: 38206965 Free PMC article.

9

Discovery and evaluation of aza-fused tricyclic derivatives for detection of Tau pathology in Alzheimer's disease.

Liu T, Li Y, Wang Y, Yan XX, Dai J, Cui M. Liu T, et al. Among authors: yan xx. Eur J Med Chem. 2023 Jan 15;246:114991. doi: 10.1016/j.ejmech.2022.114991. Epub 2022 Dec 2. Eur J Med Chem. 2023. PMID: 36493618

10

Fluorine-18-Labeled Diaryl-azines as Improved β-Amyloid Imaging Tracers: From Bench to First-in-Human Studies.

Li Y, Zhou K, Zhang X, Zhao H, Wang X, Dong R, Wang Y, Chen B, Yan XX, Dai J, Sui Y, Zhang J, Cui M. Li Y, et al. Among authors: yan xx. J Med Chem. 2023 Apr 13;66(7):4603-4616. doi: 10.1021/acs.jmedchem.2c01503. Epub 2023 Mar 18. J Med Chem. 2023. PMID: 36932961

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