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Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin.
Turner AM, Li L, Monk IR, Lee JYH, Ingle DJ, Portelli S, Sherry NL, Isles N, Seemann T, Sharkey LK, Walsh CJ, Reid GE, Nie S, Eijkelkamp BA, Holmes NE, Collis B, Vogrin S, Hiergeist A, Weber D, Gessner A, Holler E, Ascher DB, Duchene S, Scott NE, Stinear TP, Kwong JC, Gorrie CL, Howden BP, Carter GP. Turner AM, et al. Among authors: ascher db. Nature. 2024 Nov;635(8040):969-977. doi: 10.1038/s41586-024-08095-4. Epub 2024 Oct 23. Nature. 2024. PMID: 39443798 Free PMC article.
Analysis of a Novel pncA Mutation for Susceptibility to Pyrazinamide Therapy.
Karmakar M, Globan M, Fyfe JAM, Stinear TP, Johnson PDR, Holmes NE, Denholm JT, Ascher DB. Karmakar M, et al. Among authors: ascher db. Am J Respir Crit Care Med. 2018 Aug 15;198(4):541-544. doi: 10.1164/rccm.201712-2572LE. Am J Respir Crit Care Med. 2018. PMID: 29694240 Free PMC article. No abstract available.
Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae.
Vedithi SC, Rodrigues CHM, Portelli S, Skwark MJ, Das M, Ascher DB, Blundell TL, Malhotra S. Vedithi SC, et al. Among authors: ascher db. Comput Struct Biotechnol J. 2020 Jan 17;18:271-286. doi: 10.1016/j.csbj.2020.01.002. eCollection 2020. Comput Struct Biotechnol J. 2020. PMID: 32042379 Free PMC article.
ThermoMutDB: a thermodynamic database for missense mutations.
Xavier JS, Nguyen TB, Karmarkar M, Portelli S, Rezende PM, Velloso JPL, Ascher DB, Pires DEV. Xavier JS, et al. Among authors: ascher db. Nucleic Acids Res. 2021 Jan 8;49(D1):D475-D479. doi: 10.1093/nar/gkaa925. Nucleic Acids Res. 2021. PMID: 33095862 Free PMC article.
Combining structure and genomics to understand antimicrobial resistance.
Tunstall T, Portelli S, Phelan J, Clark TG, Ascher DB, Furnham N. Tunstall T, et al. Among authors: ascher db. Comput Struct Biotechnol J. 2020 Oct 29;18:3377-3394. doi: 10.1016/j.csbj.2020.10.017. eCollection 2020. Comput Struct Biotechnol J. 2020. PMID: 33294134 Free PMC article. Review.
192 results