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Granzyme B cleaves tenascin-C to release its C-terminal domain in rheumatoid arthritis.
Aubert A, Liu A, Kao M, Goeres J, Richardson KC, Nierves L, Jung K, Nabai L, Zhao H, Orend G, Krawetz R, Lange PF, Younger A, Chan J, Granville DJ. Aubert A, et al. Among authors: nabai l. JCI Insight. 2024 Oct 30;9(23):e181935. doi: 10.1172/jci.insight.181935. JCI Insight. 2024. PMID: 39475853 Free PMC article.
Granzyme B in epithelial barrier dysfunction and related skin diseases.
Jung K, Pawluk MA, Lane M, Nabai L, Granville DJ. Jung K, et al. Among authors: nabai l. Am J Physiol Cell Physiol. 2022 Jul 1;323(1):C170-C189. doi: 10.1152/ajpcell.00052.2022. Epub 2022 Apr 20. Am J Physiol Cell Physiol. 2022. PMID: 35442832 Free article. Review.
Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction.
Russo V, Klein T, Lim DJ, Solis N, Machado Y, Hiroyasu S, Nabai L, Shen Y, Zeglinski MR, Zhao H, Oram CP, Lennox PA, Van Laeken N, Carr NJ, Crawford RI, Franzke CW, Overall CM, Granville DJ. Russo V, et al. Among authors: nabai l. Sci Rep. 2018 Jun 26;8(1):9690. doi: 10.1038/s41598-018-28070-0. Sci Rep. 2018. PMID: 29946113 Free PMC article.
Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing.
Shen Y, Zeglinski MR, Turner CT, Raithatha SA, Wu Z, Russo V, Oram C, Hiroyasu S, Nabai L, Zhao H, Bozin T, Westendorf K, Kopko I, Huang R, Arns S, Tan J, Zeng H, Boey A, Liggins R, Jaquith J, Cameron DR, Papp A, Granville DJ. Shen Y, et al. Among authors: nabai l. Exp Mol Med. 2018 May 30;50(5):1-11. doi: 10.1038/s12276-018-0095-0. Exp Mol Med. 2018. PMID: 29849046 Free PMC article.
19 results