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Lessons learned from COVID-19 to overcome challenges in conducting outpatient clinical trials to find safe and effective therapeutics for the next infectious pandemic.
Oh MA, Currier J, Khan A, Mylonakis E, Newell M, Ignacio RB, Jilg N, Safdar B, Merck LH, Smith DM. Oh MA, et al. Among authors: merck lh. J Clin Transl Sci. 2024 Oct 15;8(1):e153. doi: 10.1017/cts.2024.607. eCollection 2024. J Clin Transl Sci. 2024. PMID: 39540115 Free PMC article. No abstract available.
Lessons learned from the conduct of inpatient clinical trials in a pandemic.
O'Halloran JA, Beitler JR, Chung LK, Jain MK, Khan A, Merck LH, Mourad A, Oh MA, Sharma S, Yokum T, Nayak SU. O'Halloran JA, et al. Among authors: merck lh. J Clin Transl Sci. 2024 Oct 15;8(1):e154. doi: 10.1017/cts.2024.483. eCollection 2024. J Clin Transl Sci. 2024. PMID: 39540117 Free PMC article.
Extracorporeal cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest: Lessons learned from recent clinical trials.
DeMasi S, Donohue M, Merck L, Mosier J; Strategies to Innovate Emergency Care Clinical Trials Network (SIREN) investigators. DeMasi S, et al. J Am Coll Emerg Physicians Open. 2024 Feb 29;5(2):e13129. doi: 10.1002/emp2.13129. eCollection 2024 Apr. J Am Coll Emerg Physicians Open. 2024. PMID: 38434097 Free PMC article. Review.
Acquired torticollis due to an ocular surface foreign body.
Zhang Y, Weinert MC, Schneier AJ, Merck LH, Hunter DG, Gaier ED. Zhang Y, et al. Among authors: merck lh. J AAPOS. 2024 Dec 31:104097. doi: 10.1016/j.jaapos.2024.104097. Online ahead of print. J AAPOS. 2024. PMID: 39746536
Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia: A Randomized Clinical Trial.
Collins SP, Shotwell MS, Strich JR, Gibbs KW, de Wit M, Files DC, Harkins M, Hudock K, Merck LH, Moskowitz A, Apodaca KD, Barksdale A, Safdar B, Javaheri A, Sturek JM, Schrager H, Iovine NM, Tiffany B, Douglas I, Levitt J, Ginde AA, Hager DN, Shapiro N, Duggal A, Khan A, Lanspa M, Chen P, Gentile N, Harris E, Gong M, Sellers S, Goodwin AJ, Tidswell MA, Filbin M, Desai N, Gutiérrez F, Estrada V, Burgos J, Boyles T, Paño-Pardo JR, Hussen N, Rosenberg Y, Troendle J, Bernard GR, Bistran-Hall AJ, Walsh K, Casey JD, DeClercq J, Joly MM, Pulley J, Rice TW, Schildcrout JS, Wang L, Semler MW, Self WH; ACTIV-4 Host Tissue Investigators. Collins SP, et al. Among authors: merck lh. JAMA Netw Open. 2024 Dec 2;7(12):e2448215. doi: 10.1001/jamanetworkopen.2024.48215. JAMA Netw Open. 2024. PMID: 39625722 Free PMC article. Clinical Trial.
Shock prediction with dipeptidyl peptidase-3 and renin (SPiDeR) in hypoxemic patients with COVID-19.
Busse LW, Teixeira JP, Schaich CL, Ten Lohuis CC, Nielsen ND, Sturek JM, Merck LH, Self WH, Puskarich MA, Khan A, Semler MW, Moskowitz A, Hager DN, Duggal A, Rice TW, Ginde AA, Tiffany BR, Iovine NM, Chen P, Safdar B, Gibbs KW, Javaheri A, de Wit M, Harkins MS, Joly MM, Collins SP; ACTIV-4 Host Tissue Investigators. Busse LW, et al. Among authors: merck lh. J Crit Care. 2025 Feb;85:154950. doi: 10.1016/j.jcrc.2024.154950. Epub 2024 Nov 14. J Crit Care. 2025. PMID: 39546997
Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP): study protocol for a multicenter, randomized, adaptive allocation clinical trial to identify the optimal duration of induced hypothermia for neuroprotection in comatose, adult survivors of after out-of-hospital cardiac arrest.
Meurer WJ, Schmitzberger FF, Yeatts S, Ramakrishnan V, Abella B, Aufderheide T, Barsan W, Benoit J, Berry S, Black J, Bozeman N, Broglio K, Brown J, Brown K, Carlozzi N, Caveney A, Cho SM, Chung-Esaki H, Clevenger R, Conwit R, Cooper R, Crudo V, Daya M, Harney D, Hsu C, Johnson NJ, Khan I, Khosla S, Kline P, Kratz A, Kudenchuk P, Lewis RJ, Madiyal C, Meyer S, Mosier J, Mouammar M, Neth M, O'Neil B, Paxton J, Perez S, Perman S, Sozener C, Speers M, Spiteri A, Stevenson V, Sunthankar K, Tonna J, Youngquist S, Geocadin R, Silbergleit R; ICECAP trial investigators. Meurer WJ, et al. Trials. 2024 Jul 23;25(1):502. doi: 10.1186/s13063-024-08280-w. Trials. 2024. PMID: 39044295 Free PMC article.
Early Signs of Elevated Intracranial Pressure on Computed Tomography Correlate With Measured Intracranial Pressure in the Intensive Care Unit and Six-Month Outcome After Moderate to Severe Traumatic Brain Injury.
Harder TJ, Leary OP, Yang Z, Lucke-Wold B, Liu DD, Still MEH, Zhang M, Yeatts SD, Allen JW, Wright DW, Merck D, Merck LH. Harder TJ, et al. Among authors: merck lh. J Neurotrauma. 2023 Aug;40(15-16):1603-1613. doi: 10.1089/neu.2022.0433. Epub 2023 Jun 9. J Neurotrauma. 2023. PMID: 37082956 Free PMC article.
Renin-Angiotensin System Modulation With Synthetic Angiotensin (1-7) and Angiotensin II Type 1 Receptor-Biased Ligand in Adults With COVID-19: Two Randomized Clinical Trials.
Self WH, Shotwell MS, Gibbs KW, de Wit M, Files DC, Harkins M, Hudock KM, Merck LH, Moskowitz A, Apodaca KD, Barksdale A, Safdar B, Javaheri A, Sturek JM, Schrager H, Iovine N, Tiffany B, Douglas IS, Levitt J, Busse LW, Ginde AA, Brown SM, Hager DN, Boyle K, Duggal A, Khan A, Lanspa M, Chen P, Puskarich M, Vonderhaar D, Venkateshaiah L, Gentile N, Rosenberg Y, Troendle J, Bistran-Hall AJ, DeClercq J, Lavieri R, Joly MM, Orr M, Pulley J, Rice TW, Schildcrout JS, Semler MW, Wang L, Bernard GR, Collins SP; ACTIV-4 Host Tissue Investigators. Self WH, et al. Among authors: merck lh. JAMA. 2023 Apr 11;329(14):1170-1182. doi: 10.1001/jama.2023.3546. JAMA. 2023. PMID: 37039791 Free PMC article.
45 results