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Deep brain stimulation halts Parkinson's disease-related immune dysregulation in the brain and peripheral blood.
McFleder RL, Musacchio T, Keller J, Knorr S, Petschner T, Chen JZ, Muthuraman M, Badr M, Harder-Rauschenberger L, Kremer F, Asci S, Steinhauser S, Karl AK, Brotchie JM, Koprich JB, Volkmann J, Ip CW. McFleder RL, et al. Among authors: brotchie jm. Brain Behav Immun. 2025 Jan;123:851-862. doi: 10.1016/j.bbi.2024.10.039. Epub 2024 Oct 29. Brain Behav Immun. 2025. PMID: 39481497 Free article.
Brain-to-gut trafficking of alpha-synuclein by CD11c+ cells in a mouse model of Parkinson's disease.
McFleder RL, Makhotkina A, Groh J, Keber U, Imdahl F, Peña Mosca J, Peteranderl A, Wu J, Tabuchi S, Hoffmann J, Karl AK, Pagenstecher A, Vogel J, Beilhack A, Koprich JB, Brotchie JM, Saliba AE, Volkmann J, Ip CW. McFleder RL, et al. Among authors: brotchie jm. Nat Commun. 2023 Nov 20;14(1):7529. doi: 10.1038/s41467-023-43224-z. Nat Commun. 2023. PMID: 37981650 Free PMC article.
Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease.
Matschke LA, Komadowski MA, Stöhr A, Lee B, Henrich MT, Griesbach M, Rinné S, Geibl FF, Chiu WH, Koprich JB, Brotchie JM, Kiper AK, Dolga AM, Oertel WH, Decher N. Matschke LA, et al. Among authors: brotchie jm. Sci Rep. 2022 Feb 24;12(1):3180. doi: 10.1038/s41598-022-06832-1. Sci Rep. 2022. PMID: 35210472 Free PMC article.
Neurodegeneration by α-synuclein-specific T cells in AAV-A53T-α-synuclein Parkinson's disease mice.
Karikari AA, McFleder RL, Ribechini E, Blum R, Bruttel V, Knorr S, Gehmeyr M, Volkmann J, Brotchie JM, Ahsan F, Haack B, Monoranu CM, Keber U, Yeghiazaryan R, Pagenstecher A, Heckel T, Bischler T, Wischhusen J, Koprich JB, Lutz MB, Ip CW. Karikari AA, et al. Among authors: brotchie jm. Brain Behav Immun. 2022 Mar;101:194-210. doi: 10.1016/j.bbi.2022.01.007. Epub 2022 Jan 12. Brain Behav Immun. 2022. PMID: 35032575 Free article.
195 results