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Page 1
Ubiquitin is a chemist's playground.
Farnung J, Schulman BA. Farnung J, et al. Among authors: schulman ba. Nat Chem. 2024 Nov;16(11):1918. doi: 10.1038/s41557-024-01660-4. Nat Chem. 2024. PMID: 39482375 No abstract available.
NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly.
Baek K, Krist DT, Prabu JR, Hill S, Klügel M, Neumaier LM, von Gronau S, Kleiger G, Schulman BA. Baek K, et al. Among authors: schulman ba. Nature. 2020 Feb;578(7795):461-466. doi: 10.1038/s41586-020-2000-y. Epub 2020 Feb 12. Nature. 2020. PMID: 32051583 Free PMC article.
Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
Horn-Ghetko D, Krist DT, Prabu JR, Baek K, Mulder MPC, Klügel M, Scott DC, Ovaa H, Kleiger G, Schulman BA. Horn-Ghetko D, et al. Among authors: schulman ba. Nature. 2021 Feb;590(7847):671-676. doi: 10.1038/s41586-021-03197-9. Epub 2021 Feb 3. Nature. 2021. PMID: 33536622 Free PMC article.
Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation.
Kagiou C, Cisneros JA, Farnung J, Liwocha J, Offensperger F, Dong K, Yang K, Tin G, Horstmann CS, Hinterndorfer M, Paulo JA, Scholes NS, Sanchez Avila J, Fellner M, Andersch F, Hannich JT, Zuber J, Kubicek S, Gygi SP, Schulman BA, Winter GE. Kagiou C, et al. Among authors: schulman ba. Nat Commun. 2024 Jun 26;15(1):5409. doi: 10.1038/s41467-024-49739-3. Nat Commun. 2024. PMID: 38926334 Free PMC article.
Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases.
Scott DC, Chittori S, Purser N, King MT, Maiwald SA, Churion K, Nourse A, Lee C, Paulo JA, Miller DJ, Elledge SJ, Harper JW, Kleiger G, Schulman BA. Scott DC, et al. Among authors: schulman ba. Nat Commun. 2024 Nov 15;15(1):9899. doi: 10.1038/s41467-024-54126-z. Nat Commun. 2024. PMID: 39548056 Free PMC article.
Molecular glue concept solidifies.
Baek K, Schulman BA. Baek K, et al. Among authors: schulman ba. Nat Chem Biol. 2020 Jan;16(1):2-3. doi: 10.1038/s41589-019-0414-3. Nat Chem Biol. 2020. PMID: 31819271 No abstract available.
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch KP, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S, Dikic I. Shin D, et al. Among authors: schulman ba. Nature. 2020 Nov;587(7835):657-662. doi: 10.1038/s41586-020-2601-5. Epub 2020 Jul 29. Nature. 2020. PMID: 32726803 Free PMC article.
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.
Liwocha J, Krist DT, van der Heden van Noort GJ, Hansen FM, Truong VH, Karayel O, Purser N, Houston D, Burton N, Bostock MJ, Sattler M, Mann M, Harrison JS, Kleiger G, Ovaa H, Schulman BA. Liwocha J, et al. Among authors: schulman ba. Nat Chem Biol. 2021 Mar;17(3):272-279. doi: 10.1038/s41589-020-00696-0. Epub 2020 Dec 7. Nat Chem Biol. 2021. PMID: 33288957 Free PMC article.
202 results