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Nanoparticles encapsulating phosphatidylinositol derivatives promote neuroprotection and functional improvement in preclinical models of ALS via a long-lasting activation of TRPML1 lysosomal channel.
Tedeschi V, Nele V, Valsecchi V, Anzilotti S, Vinciguerra A, Zucaro L, Sisalli MJ, Cassiano C, De Iesu N, Pignataro G, Canzoniero LMT, Pannaccione A, De Rosa G, Secondo A. Tedeschi V, et al. Among authors: pignataro g. Pharmacol Res. 2024 Dec;210:107491. doi: 10.1016/j.phrs.2024.107491. Epub 2024 Nov 2. Pharmacol Res. 2024. PMID: 39491634 Free article.
Dysregulated balance of D- and L-amino acids modulating glutamatergic neurotransmission in severe spinal muscular atrophy.
Hassan A, di Vito R, Nuzzo T, Vidali M, Carlini MJ, Yadav S, Yang H, D'Amico A, Kolici X, Valsecchi V, Panicucci C, Pignataro G, Bruno C, Bertini E, Errico F, Pellizzoni L, Usiello A. Hassan A, et al. Among authors: pignataro g. bioRxiv [Preprint]. 2024 Oct 22:2024.10.22.619645. doi: 10.1101/2024.10.22.619645. bioRxiv. 2024. PMID: 39484528 Free PMC article. Preprint.
Systemic administration of blood-derived exosomes induced by remote ischemic post-conditioning, by delivering a specific cluster of miRNAs, ameliorates ischemic damage and neurological function.
Cuomo O, Anzilotti S, Brancaccio P, Cepparulo P, Lombardi G, Viscardi V, Vinciguerra A, Annunziato L, Pignataro G. Cuomo O, et al. Among authors: pignataro g. J Cereb Blood Flow Metab. 2024 Dec;44(12):1459-1471. doi: 10.1177/0271678X241270284. Epub 2024 Aug 11. J Cereb Blood Flow Metab. 2024. PMID: 39129187
Newly Synthesized Indolylacetic Derivatives Reduce Tumor Necrosis Factor-Mediated Neuroinflammation and Prolong Survival in Amyotrophic Lateral Sclerosis Mice.
Corvino A, Caliendo G, Fiorino F, Frecentese F, Valsecchi V, Lombardi G, Anzilotti S, Andreozzi G, Scognamiglio A, Sparaco R, Perissutti E, Severino B, Gargiulo M, Santagada V, Pignataro G. Corvino A, et al. Among authors: pignataro g. ACS Pharmacol Transl Sci. 2024 Jun 22;7(7):1996-2005. doi: 10.1021/acsptsci.4c00098. eCollection 2024 Jul 12. ACS Pharmacol Transl Sci. 2024. PMID: 39022351
203 results