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Slow-Binding and Covalent HDAC Inhibition: A New Paradigm?
Raouf YS, Moreno-Yruela C. Raouf YS, et al. Among authors: moreno yruela c. JACS Au. 2024 Oct 31;4(11):4148-4161. doi: 10.1021/jacsau.4c00828. eCollection 2024 Nov 25. JACS Au. 2024. PMID: 39610753 Free PMC article. Review.
Distribution and diversity of classical deacylases in bacteria.
Graf LG, Moreno-Yruela C, Qin C, Schulze S, Palm GJ, Schmöker O, Wang N, Hocking DM, Jebeli L, Girbardt B, Berndt L, Dörre B, Weis DM, Janetzky M, Albrecht D, Zühlke D, Sievers S, Strugnell RA, Olsen CA, Hofmann K, Lammers M. Graf LG, et al. Among authors: moreno yruela c. Nat Commun. 2024 Nov 3;15(1):9496. doi: 10.1038/s41467-024-53903-0. Nat Commun. 2024. PMID: 39489725 Free PMC article.
Lysine L-lactylation is the dominant lactylation isomer induced by glycolysis.
Zhang D, Gao J, Zhu Z, Mao Q, Xu Z, Singh PK, Rimayi CC, Moreno-Yruela C, Xu S, Li G, Sin YC, Chen Y, Olsen CA, Snyder NW, Dai L, Li L, Zhao Y. Zhang D, et al. Among authors: moreno yruela c. Nat Chem Biol. 2025 Jan;21(1):91-99. doi: 10.1038/s41589-024-01680-8. Epub 2024 Jul 19. Nat Chem Biol. 2025. PMID: 39030363 Free PMC article.
Class I histone deacetylases (HDAC1-3) are histone lysine delactylases.
Moreno-Yruela C, Zhang D, Wei W, Bæk M, Liu W, Gao J, Danková D, Nielsen AL, Bolding JE, Yang L, Jameson ST, Wong J, Olsen CA, Zhao Y. Moreno-Yruela C, et al. Sci Adv. 2022 Jan 21;8(3):eabi6696. doi: 10.1126/sciadv.abi6696. Epub 2022 Jan 19. Sci Adv. 2022. PMID: 35044827 Free PMC article.
Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration.
Nielsen AL, Rajabi N, Kudo N, Lundø K, Moreno-Yruela C, Bæk M, Fontenas M, Lucidi A, Madsen AS, Yoshida M, Olsen CA. Nielsen AL, et al. Among authors: moreno yruela c. RSC Chem Biol. 2021 Jan 14;2(2):612-626. doi: 10.1039/d0cb00036a. eCollection 2021 Apr 1. RSC Chem Biol. 2021. PMID: 34458803 Free PMC article.
14 results