Gursky O - Search Results

1

Conformational Differences in the Light Chain Constant Domain of Immunoglobulin G and Free Light Chain May Influence Proteolysis in AL Amyloidosis.

Klimtchuk ES, Prokaeva T, Spencer BH, Wong S, Ghosh S, Urdaneta A, Morgan G, Wales TE, Gursky O. Klimtchuk ES, et al. Among authors: gursky o. J Mol Biol. 2024 Dec 1;436(23):168837. doi: 10.1016/j.jmb.2024.168837. Epub 2024 Oct 28. J Mol Biol. 2024. PMID: 39490919

2

Differential stability of high-density lipoprotein subclasses: effects of particle size and protein composition.

Gao X, Yuan S, Jayaraman S, Gursky O. Gao X, et al. Among authors: gursky o. J Mol Biol. 2009 Apr 3;387(3):628-38. doi: 10.1016/j.jmb.2009.02.036. Epub 2009 Feb 21. J Mol Biol. 2009. PMID: 19236880 Free PMC article.

3

The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chain.

Klimtchuk ES, Gursky O, Patel RS, Laporte KL, Connors LH, Skinner M, Seldin DC. Klimtchuk ES, et al. Among authors: gursky o. Biochemistry. 2010 Nov 16;49(45):9848-57. doi: 10.1021/bi101351c. Epub 2010 Oct 20. Biochemistry. 2010. PMID: 20936823 Free PMC article.

4

Crystal structure of Δ(185-243)ApoA-I suggests a mechanistic framework for the protein adaptation to the changing lipid load in good cholesterol: from flatland to sphereland via double belt, belt buckle, double hairpin and trefoil/tetrafoil.

Gursky O. Gursky O. J Mol Biol. 2013 Jan 9;425(1):1-16. doi: 10.1016/j.jmb.2012.09.027. Epub 2012 Oct 4. J Mol Biol. 2013. PMID: 23041415 Free PMC article.

5

Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic?

Das M, Wilson CJ, Mei X, Wales TE, Engen JR, Gursky O. Das M, et al. Among authors: gursky o. J Mol Biol. 2016 Jan 29;428(2 Pt B):449-62. doi: 10.1016/j.jmb.2015.10.029. Epub 2015 Nov 10. J Mol Biol. 2016. PMID: 26562506 Free PMC article.

6

Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic?

Das M, Wilson CJ, Mei X, Wales T, Engen JR, Gursky O. Das M, et al. Among authors: gursky o. Amyloid. 2017 Mar;24(sup1):11-12. doi: 10.1080/13506129.2016.1269737. Epub 2016 Dec 31. Amyloid. 2017. PMID: 28042708 Free PMC article. No abstract available.

7

In vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis.

Klimtchuk ES, Prokaeva TB, Spencer BH, Gursky O, Connors LH. Klimtchuk ES, et al. Among authors: gursky o. Amyloid. 2017 Jun;24(2):115-122. doi: 10.1080/13506129.2017.1336996. Epub 2017 Jun 20. Amyloid. 2017. PMID: 28632419 Free PMC article.

8

Hereditary Renal Amyloidosis Associated With a Novel Apolipoprotein A-II Variant.

Prokaeva T, Akar H, Spencer B, Havasi A, Cui H, O'Hara CJ, Gursky O, Leszyk J, Steffen M, Browning S, Rosenberg A, Connors LH. Prokaeva T, et al. Among authors: o hara cj, gursky o. Kidney Int Rep. 2017 Jul 29;2(6):1223-1232. doi: 10.1016/j.ekir.2017.07.009. eCollection 2017 Nov. Kidney Int Rep. 2017. PMID: 29270531 Free PMC article. No abstract available.

9

Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease.

Klimtchuk ES, Prokaeva T, Frame NM, Abdullahi HA, Spencer B, Dasari S, Cui H, Berk JL, Kurtin PJ, Connors LH, Gursky O. Klimtchuk ES, et al. Among authors: gursky o. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6428-E6436. doi: 10.1073/pnas.1802977115. Epub 2018 Jun 25. Proc Natl Acad Sci U S A. 2018. PMID: 29941560 Free PMC article.

10

Structural Basis for Lipid Binding and Function by an Evolutionarily Conserved Protein, Serum Amyloid A.

Frame NM, Kumanan M, Wales TE, Bandara A, Fändrich M, Straub JE, Engen JR, Gursky O. Frame NM, et al. Among authors: gursky o. J Mol Biol. 2020 Mar 27;432(7):1978-1995. doi: 10.1016/j.jmb.2020.01.029. Epub 2020 Feb 6. J Mol Biol. 2020. PMID: 32035904 Free PMC article.

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