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Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging.
Ma S, Ji Z, Zhang B, Geng L, Cai Y, Nie C, Li J, Zuo Y, Sun Y, Xu G, Liu B, Ai J, Liu F, Zhao L, Zhang J, Zhang H, Sun S, Huang H, Zhang Y, Ye Y, Fan Y, Zheng F, Hu J, Zhang B, Li J, Feng X, Zhang F, Zhuang Y, Li T, Yu Y, Bao Z, Pan S, Rodriguez Esteban C, Liu Z, Deng H, Wen F, Song M, Wang S, Zhu G, Yang J, Jiang T, Song W, Izpisua Belmonte JC, Qu J, Zhang W, Gu Y, Liu GH. Ma S, et al. Among authors: cai y. Cell. 2024 Nov 27;187(24):7025-7044.e34. doi: 10.1016/j.cell.2024.10.019. Epub 2024 Nov 4. Cell. 2024. PMID: 39500323
Single-nucleus transcriptomic landscape of primate hippocampal aging.
Zhang H, Li J, Ren J, Sun S, Ma S, Zhang W, Yu Y, Cai Y, Yan K, Li W, Hu B, Chan P, Zhao GG, Belmonte JCI, Zhou Q, Qu J, Wang S, Liu GH. Zhang H, et al. Among authors: cai y. Protein Cell. 2021 Sep;12(9):695-716. doi: 10.1007/s13238-021-00852-9. Epub 2021 May 30. Protein Cell. 2021. PMID: 34052996 Free PMC article.
A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis.
Huang D, Zuo Y, Zhang C, Sun G, Jing Y, Lei J, Ma S, Sun S, Lu H, Cai Y, Zhang W, Gao F, Peng Xiang A, Belmonte JCI, Liu GH, Qu J, Wang S. Huang D, et al. Among authors: cai y. Protein Cell. 2023 Dec 1;14(12):888-907. doi: 10.1093/procel/pwac057. Protein Cell. 2023. PMID: 36929025 Free PMC article.
Low-dose chloroquine treatment extends the lifespan of aged rats.
Li W, Zou Z, Cai Y, Yang K, Wang S, Liu Z, Geng L, Chu Q, Ji Z, Chan P, Liu GH, Song M, Qu J, Zhang W. Li W, et al. Among authors: cai y. Protein Cell. 2022 Jun;13(6):454-461. doi: 10.1007/s13238-021-00903-1. Protein Cell. 2022. PMID: 35023015 Free PMC article. No abstract available.
Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor.
Liu Z, Li W, Geng L, Sun L, Wang Q, Yu Y, Yan P, Liang C, Ren J, Song M, Zhao Q, Lei J, Cai Y, Li J, Yan K, Wu Z, Chu Q, Li J, Wang S, Li C, Han JJ, Hernandez-Benitez R, Shyh-Chang N, Belmonte JCI, Zhang W, Qu J, Liu GH. Liu Z, et al. Among authors: cai y. Cell Discov. 2022 Feb 1;8(1):6. doi: 10.1038/s41421-021-00361-3. Cell Discov. 2022. PMID: 35102134 Free PMC article.
The landscape of aging.
Cai Y, Song W, Li J, Jing Y, Liang C, Zhang L, Zhang X, Zhang W, Liu B, An Y, Li J, Tang B, Pei S, Wu X, Liu Y, Zhuang CL, Ying Y, Dou X, Chen Y, Xiao FH, Li D, Yang R, Zhao Y, Wang Y, Wang L, Li Y, Ma S, Wang S, Song X, Ren J, Zhang L, Wang J, Zhang W, Xie Z, Qu J, Wang J, Xiao Y, Tian Y, Wang G, Hu P, Ye J, Sun Y, Mao Z, Kong QP, Liu Q, Zou W, Tian XL, Xiao ZX, Liu Y, Liu JP, Song M, Han JJ, Liu GH. Cai Y, et al. Sci China Life Sci. 2022 Dec;65(12):2354-2454. doi: 10.1007/s11427-022-2161-3. Epub 2022 Sep 2. Sci China Life Sci. 2022. PMID: 36066811 Free PMC article. Review.
Resurrection of endogenous retroviruses during aging reinforces senescence.
Liu X, Liu Z, Wu Z, Ren J, Fan Y, Sun L, Cao G, Niu Y, Zhang B, Ji Q, Jiang X, Wang C, Wang Q, Ji Z, Li L, Esteban CR, Yan K, Li W, Cai Y, Wang S, Zheng A, Zhang YE, Tan S, Cai Y, Song M, Lu F, Tang F, Ji W, Zhou Q, Belmonte JCI, Zhang W, Qu J, Liu GH. Liu X, et al. Among authors: cai y. Cell. 2023 Jan 19;186(2):287-304.e26. doi: 10.1016/j.cell.2022.12.017. Epub 2023 Jan 6. Cell. 2023. PMID: 36610399 Free article.
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