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Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis.
Han Y, Byun J, Zhu C, Sun R, Roh JY, Cordell HJ, Lee HS, Shaw VR, Kang SW, Razjouyan J, Cooley MA, Hassan MM, Siminovitch KA, Folseraas T, Ellinghaus D, Bergquist A, Rushbrook SM, Franke A, Karlsen TH, Lazaridis KN; International PSC Study Group; McGlynn KA, Roberts LR, Amos CI. Han Y, et al. Among authors: rushbrook sm. Nat Commun. 2023 Feb 24;14(1):1069. doi: 10.1038/s41467-023-36678-8. Nat Commun. 2023. PMID: 36828809 Free PMC article.
APOBEC mutagenesis is a common process in normal human small intestine.
Wang Y, Robinson PS, Coorens THH, Moore L, Lee-Six H, Noorani A, Sanders MA, Jung H, Katainen R, Heuschkel R, Brunton-Sim R, Weston R, Read D, Nobbs B, Fitzgerald RC, Saeb-Parsy K, Martincorena I, Campbell PJ, Rushbrook S, Zilbauer M, Buczacki SJA, Stratton MR. Wang Y, et al. Nat Genet. 2023 Feb;55(2):246-254. doi: 10.1038/s41588-022-01296-5. Epub 2023 Jan 26. Nat Genet. 2023. PMID: 36702998 Free PMC article.
Regulation of intestinal senescence during cholestatic liver disease modulates barrier function and liver disease progression.
Moreno-Gonzalez M, Hampton K, Ruiz P, Beasy G, Nagies FS, Parker A, Lazenby J, Bone C, Alava-Arteaga A, Patel M, Hellmich C, Luri-Martin P, Silan E, Philo M, Baker D, Rushbrook SM, Hildebrand F, Rushworth SA, Beraza N. Moreno-Gonzalez M, et al. Among authors: rushbrook sm. JHEP Rep. 2024 Jun 29;6(10):101159. doi: 10.1016/j.jhepr.2024.101159. eCollection 2024 Oct. JHEP Rep. 2024. PMID: 39314550 Free PMC article.
A protocol paper for the MOTION Study-A longitudinal study in a cohort aged 60 years and older to obtain mechanistic knowledge of the role of the gut microbiome during normal healthy ageing in order to develop strategies that will improve lifelong health and wellbeing.
Phillips S, Watt R, Atkinson T, Rajan S, Hayhoe A, Savva GM, Hornberger M, Burton BJL, Saada J, Cambell-Kelly M, Rushbrook S, Carding SR. Phillips S, et al. PLoS One. 2022 Nov 18;17(11):e0276118. doi: 10.1371/journal.pone.0276118. eCollection 2022. PLoS One. 2022. PMID: 36399457 Free PMC article.
Guidelines Development Group for the British Society of Gastroenterology guidelines for the diagnosis and management of cholangiocarcinoma.
Khan SA, Rushbrook SM, Kendall TJ, Zen Y, Albazaz R, Manoharan P, Pereira SP, Sturgess R, Davidson BR, Malik HZ, Manas D, Heaton N, Prasad KR, Valle JW, Goody R, Hawkins M, Prentice W, Morement H, Walmsley M, Bridgewater J. Khan SA, et al. Among authors: rushbrook sm. Gut. 2024 Aug 19:gutjnl-2024-333359. doi: 10.1136/gutjnl-2024-333359. Online ahead of print. Gut. 2024. PMID: 39160057 Free article. No abstract available.
HLA-DPA1*02:01~B1*01:01 is a risk haplotype for primary sclerosing cholangitis mediating activation of NKp44+ NK cells.
Zecher BF, Ellinghaus D, Schloer S, Niehrs A, Padoan B, Baumdick ME, Yuki Y, Martin MP, Glow D, Schröder-Schwarz J, Niersch J, Brias S, Müller LM, Habermann R, Kretschmer P, Früh T, Dänekas J, Wehmeyer MH, Poch T, Sebode M; International PSC Study Group (IPSCSG); Ellinghaus E, Degenhardt F, Körner C, Hoelzemer A, Fehse B, Oldhafer KJ, Schumacher U, Sauter G, Carrington M, Franke A, Bunders MJ, Schramm C, Altfeld M. Zecher BF, et al. Gut. 2024 Jan 5;73(2):325-337. doi: 10.1136/gutjnl-2023-329524. Gut. 2024. PMID: 37788895 Free PMC article.
Regulation of immune responses in primary biliary cholangitis: a transcriptomic analysis of peripheral immune cells.
Mulcahy V, Liaskou E, Martin JE, Kotagiri P, Badrock J, Jones RL, Rushbrook SM, Ryder SD, Thorburn D, Taylor-Robinson SD, Clark G, Cordell HJ, Sandford RN, Jones DE, Hirschfield GM, Mells GF. Mulcahy V, et al. Among authors: rushbrook sm. Hepatol Commun. 2023 Apr 4;7(4):e0110. doi: 10.1097/HC9.0000000000000110. eCollection 2023 Apr 1. Hepatol Commun. 2023. PMID: 37026715 Free PMC article.
43 results