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Page 1
Macrophage LRRK2 hyperactivity impairs autophagy and induces Paneth cell dysfunction.
Sun S, Hodel M, Wang X, De Vicente J, Haritunians T, Debebe A, Hung CT, Ma C, Malique A, Nguyen HN, Agam M, Maloney MT, Goo MS, Kluss JH, Mishra R, Frein J, Foster A, Ballentine S, Pandey U, Kern J, Yang S, Mengesha E, Balasubramanian I, Arguello A, Estrada AA, Gao N, Peter I, McGovern DPB, Henry AG, Stappenbeck TS, Liu TC. Sun S, et al. Among authors: de vicente j. Sci Immunol. 2024 Nov 8;9(101):eadi7907. doi: 10.1126/sciimmunol.adi7907. Epub 2024 Nov 8. Sci Immunol. 2024. PMID: 39514635
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease.
Jennings D, Huntwork-Rodriguez S, Henry AG, Sasaki JC, Meisner R, Diaz D, Solanoy H, Wang X, Negrou E, Bondar VV, Ghosh R, Maloney MT, Propson NE, Zhu Y, Maciuca RD, Harris L, Kay A, LeWitt P, King TA, Kern D, Ellenbogen A, Goodman I, Siderowf A, Aldred J, Omidvar O, Masoud ST, Davis SS, Arguello A, Estrada AA, de Vicente J, Sweeney ZK, Astarita G, Borin MT, Wong BK, Wong H, Nguyen H, Scearce-Levie K, Ho C, Troyer MD. Jennings D, et al. Among authors: de vicente j. Sci Transl Med. 2022 Jun 8;14(648):eabj2658. doi: 10.1126/scitranslmed.abj2658. Epub 2022 Jun 8. Sci Transl Med. 2022. PMID: 35675433
Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases.
Craig RA 2nd, De Vicente J, Estrada AA, Feng JA, Lexa KW, Canet MJ, Dowdle WE, Erickson RI, Flores BN, Haddick PCG, Kane LA, Lewcock JW, Moerke NJ, Poda SB, Sweeney Z, Takahashi RH, Tong V, Wang J, Yulyaningsih E, Solanoy H, Scearce-Levie K, Sanchez PE, Tang L, Xu M, Zhang R, Osipov M. Craig RA 2nd, et al. Among authors: de vicente j. J Med Chem. 2024 Apr 11;67(7):5758-5782. doi: 10.1021/acs.jmedchem.3c02422. Epub 2024 Mar 21. J Med Chem. 2024. PMID: 38511649
Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
Craig RA 2nd, Fox BM, Hu C, Lexa KW, Osipov M, Thottumkara AP, Larhammar M, Miyamoto T, Rana A, Kane LA, Yulyaningsih E, Solanoy H, Nguyen H, Chau R, Earr T, Kajiwara Y, Fleck D, Lucas A, Haddick PCG, Takahashi RH, Tong V, Wang J, Canet MJ, Poda SB, Scearce-Levie K, Srivastava A, Sweeney ZK, Xu M, Zhang R, He J, Lei Y, Zhuo Z, de Vicente J. Craig RA 2nd, et al. Among authors: de vicente j. J Med Chem. 2022 Dec 22;65(24):16290-16312. doi: 10.1021/acs.jmedchem.2c01056. Epub 2022 Dec 5. J Med Chem. 2022. PMID: 36469401
Design and evaluation of a bilayered dermal/hypodermal 3D model using a biomimetic hydrogel formulation.
Chocarro-Wrona C, López de Andrés J, Rioboó-Legaspi P, Pleguezuelos-Beltrán P, Antich C, De Vicente J, Gálvez-Martín P, López-Ruiz E, Marchal JA. Chocarro-Wrona C, et al. Among authors: de vicente j. Biomed Pharmacother. 2024 Aug;177:117051. doi: 10.1016/j.biopha.2024.117051. Epub 2024 Jul 2. Biomed Pharmacother. 2024. PMID: 38959608 Free article.
Tumor-Intrinsic Perinuclear LOXL2: Prognostic Relevance and Relationship with YAP1 Activation Status in Oral Squamous Cell Carcinoma.
Rodrigo JP, Moreno-Bueno G, Lequerica-Fernández P, Rodríguez-Santamarta T, Díaz E, Prieto-Fernández L, Álvarez-Teijeiro S, García-Pedrero JM, de Vicente JC. Rodrigo JP, et al. Among authors: de vicente jc. Pathobiology. 2024;91(6):422-433. doi: 10.1159/000539928. Epub 2024 Jun 27. Pathobiology. 2024. PMID: 38934185 Free PMC article.
Lectin-like Transcript-1 (LLT1) Expression in Oral Squamous Cell Carcinomas: Prognostic Significance and Relationship with the Tumor Immune Microenvironment.
de Vicente JC, Lequerica-Fernández P, Rodrigo JP, Rodríguez-Santamarta T, Blanco-Lorenzo V, Prieto-Fernández L, Corte-Torres D, Vallina A, Domínguez-Iglesias F, Álvarez-Teijeiro S, García-Pedrero JM. de Vicente JC, et al. Int J Mol Sci. 2024 Apr 13;25(8):4314. doi: 10.3390/ijms25084314. Int J Mol Sci. 2024. PMID: 38673902 Free PMC article.
Prognostic Significance of β-Catenin in Relation to the Tumor Immune Microenvironment in Oral Cancer.
Lequerica-Fernández P, Rodríguez-Santamarta T, García-García E, Blanco-Lorenzo V, Torres-Rivas HE, Rodrigo JP, Suárez-Sánchez FJ, García-Pedrero JM, De Vicente JC. Lequerica-Fernández P, et al. Among authors: de vicente jc. Biomedicines. 2023 Sep 29;11(10):2675. doi: 10.3390/biomedicines11102675. Biomedicines. 2023. PMID: 37893049 Free PMC article.
219 results