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Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition.
Vora S, Andrew A, Kumar RP, Nazareth D, Bonfim-Melo A, Lim Y, Ong XY, Fernando M, He Y, Hooper JD, McMillan NA, Urosevic J, Travers J, Saeh J, Kumar S, Jones MJ, Gabrielli B. Vora S, et al. Among authors: mcmillan na. Cell Death Dis. 2024 Nov 9;15(11):810. doi: 10.1038/s41419-024-07204-5. Cell Death Dis. 2024. PMID: 39521795 Free PMC article.
Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer.
Gabrielli B, Bokhari F, Ranall MV, Oo ZY, Stevenson AJ, Wang W, Murrell M, Shaikh M, Fallaha S, Clarke D, Kelly M, Sedelies K, Christensen M, McKee S, Leggatt G, Leo P, Skalamera D, Soyer HP, Gonda TJ, McMillan NA. Gabrielli B, et al. Among authors: mcmillan na. Mol Cancer Ther. 2015 Dec;14(12):2753-61. doi: 10.1158/1535-7163.MCT-15-0506. Epub 2015 Oct 29. Mol Cancer Ther. 2015. PMID: 26516156
Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells.
Vora S, Chatterjee S, Andrew A, Kumar RP, Proctor M, Zeng Z, Bhatt R, Nazareth D, Fernando M, Jones MJK, He Y, Hooper JD, McMillan NAJ, Urosevic J, Saeh J, Travers J, Cimini D, Chen J, Gabrielli B. Vora S, et al. Among authors: mcmillan naj. Cell Death Dis. 2025 Jan 8;16(1):7. doi: 10.1038/s41419-024-07329-7. Cell Death Dis. 2025. PMID: 39779678 Free PMC article.
138 results