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Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes.
Guo JL, Braun D, Fitzgerald GA, Hsieh YT, Rougé L, Litvinchuk A, Steffek M, Propson NE, Heffner CM, Discenza C, Han SJ, Rana A, Skuja LL, Lin BQ, Sun EW, Davis SS, Balasundar S, Becerra I, Dugas JC, Ha C, Hsiao-Nakamoto J, Huang F, Jain S, Kung JE, Liau NPD, Mahon CS, Nguyen HN, Nguyen N, Samaddar M, Shi Y, Tatarakis D, Tian Y, Zhu Y, Suh JH, Sandmann T, Calvert MEK, Arguello A, Kane LA, Lewcock JW, Holtzman DM, Koth CM, Di Paolo G. Guo JL, et al. Among authors: holtzman dm. Cell. 2024 Nov 11:S0092-8674(24)01209-1. doi: 10.1016/j.cell.2024.10.027. Online ahead of print. Cell. 2024. PMID: 39532095 Free article.
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist.
Litvinchuk A, Suh JH, Guo JL, Lin K, Davis SS, Bien-Ly N, Tycksen E, Tabor GT, Remolina Serrano J, Manis M, Bao X, Lee C, Bosch M, Perez EJ, Yuede CM, Cashikar AG, Ulrich JD, Di Paolo G, Holtzman DM. Litvinchuk A, et al. Among authors: holtzman dm. Neuron. 2024 Feb 7;112(3):384-403.e8. doi: 10.1016/j.neuron.2023.10.023. Epub 2023 Nov 22. Neuron. 2024. PMID: 37995685
APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread.
Chen Y, Song S, Parhizkar S, Lord J, Zhu Y, Strickland MR, Wang C, Park J, Tabor GT, Jiang H, Li K, Davis AA, Yuede CM, Colonna M, Ulrich JD, Holtzman DM. Chen Y, et al. Among authors: holtzman dm. Cell. 2024 Jan 18;187(2):428-445.e20. doi: 10.1016/j.cell.2023.11.029. Epub 2023 Dec 11. Cell. 2024. PMID: 38086389
Hallmarks of neurodegenerative diseases.
Wilson DM 3rd, Cookson MR, Van Den Bosch L, Zetterberg H, Holtzman DM, Dewachter I. Wilson DM 3rd, et al. Among authors: holtzman dm. Cell. 2023 Feb 16;186(4):693-714. doi: 10.1016/j.cell.2022.12.032. Cell. 2023. PMID: 36803602 Free article. Review.
APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease.
Jackson RJ, Keiser MS, Meltzer JC, Fykstra DP, Dierksmeier SE, Hajizadeh S, Kreuzer J, Morris R, Melloni A, Nakajima T, Tecedor L, Ranum PT, Carrell E, Chen Y, Nishtar MA, Holtzman DM, Haas W, Davidson BL, Hyman BT. Jackson RJ, et al. Among authors: holtzman dm. Mol Ther. 2024 May 1;32(5):1373-1386. doi: 10.1016/j.ymthe.2024.03.024. Epub 2024 Mar 19. Mol Ther. 2024. PMID: 38504517 Free article.
Tauopathy severely disrupts homeostatic set-points in emergent neural dynamics but not in the activity of individual neurons.
McGregor JN, Farris CA, Ensley S, Schneider A, Wang C, Liu Y, Tu J, Elmore H, Ronayne KD, Wessel R, Dyer EL, Bhaskaran-Nair K, Holtzman DM, Hengen KB. McGregor JN, et al. Among authors: holtzman dm. bioRxiv [Preprint]. 2023 Sep 6:2023.09.01.555947. doi: 10.1101/2023.09.01.555947. bioRxiv. 2023. PMID: 37732214 Free PMC article. Preprint.
640 results