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Page 1
Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome.
Mackay A, Velcicky J, Gommermann N, Mattes H, Janser P, Wright M, Dubois C, Brenneisen S, Ilic S, Vangrevelinghe E, Stiefl N, Boettcher A, Schoenboerner M, Vogelsanger M, Muller-Bentz S, Kamke M, Rubert J, Kauffmann M, Desrayaud S, Trunzer M, Srinivas H, Hinniger A, von Burg N, Beltz K, Dekker C, Farady CJ. Mackay A, et al. Among authors: farady cj. J Med Chem. 2024 Dec 12;67(23):20780-20798. doi: 10.1021/acs.jmedchem.4c02350. Epub 2024 Nov 22. J Med Chem. 2024. PMID: 39574318
Clonal Hematopoiesis of Indeterminate Potential With Loss of Tet2 Enhances Risk for Atrial Fibrillation Through Nlrp3 Inflammasome Activation.
Lin AE, Bapat AC, Xiao L, Niroula A, Ye J, Wong WJ, Agrawal M, Farady CJ, Boettcher A, Hergott CB, McConkey M, Flores-Bringas P, Shkolnik V, Bick AG, Milan D, Natarajan P, Libby P, Ellinor PT, Ebert BL. Lin AE, et al. Among authors: farady cj. Circulation. 2024 Apr 30;149(18):1419-1434. doi: 10.1161/CIRCULATIONAHA.123.065597. Epub 2024 Feb 15. Circulation. 2024. PMID: 38357791 Free PMC article.
IL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells.
Rai S, Zhang Y, Grockowiak E, Kimmerlin Q, Hansen N, Stoll CB, Usart M, Luque Paz D, Hao-Shen H, Zhu Y, Roux J, Bader MS, Dirnhofer S, Farady CJ, Schroeder T, Méndez-Ferrer S, Skoda RC. Rai S, et al. Among authors: farady cj. Blood Adv. 2024 Mar 12;8(5):1234-1249. doi: 10.1182/bloodadvances.2023011338. Blood Adv. 2024. PMID: 38207211 Free PMC article.
Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors.
Velcicky J, Janser P, Gommermann N, Brenneisen S, Ilic S, Vangrevelinghe E, Stiefl N, Boettcher A, Arnold C, Malinverni C, Dawson J, Murgasova R, Desrayaud S, Beltz K, Hinniger A, Dekker C, Farady CJ, Mackay A. Velcicky J, et al. Among authors: farady cj. J Med Chem. 2024 Jan 25;67(2):1544-1562. doi: 10.1021/acs.jmedchem.3c02098. Epub 2024 Jan 4. J Med Chem. 2024. PMID: 38175811
HDAC6/aggresome processing pathway importance for inflammasome formation is context dependent.
Wang L, Unterreiner A, Kapetanovic R, Aslani S, Xiong Y, Donovan KA, Farady CJ, Fischer ES, Bornancin F, Matthias P. Wang L, et al. Among authors: farady cj. bioRxiv [Preprint]. 2023 Aug 15:2023.08.15.553363. doi: 10.1101/2023.08.15.553363. bioRxiv. 2023. Update in: J Biol Chem. 2024 Feb;300(2):105638. doi: 10.1016/j.jbc.2024.105638 PMID: 37645730 Free PMC article. Updated. Preprint.
Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis.
Neuwirt E, Magnani G, Ćiković T, Wöhrle S, Fischer L, Kostina A, Flemming S, Fischenich NJ, Saller BS, Gorka O, Renner S, Agarinis C, Parker CN, Boettcher A, Farady CJ, Kesselring R, Berlin C, Backofen R, Rodriguez-Franco M, Kreutz C, Prinz M, Tholen M, Reinheckel T, Ott T, Groß CJ, Jost PJ, Groß O. Neuwirt E, et al. Among authors: farady cj. Sci Signal. 2023 Jan 17;16(768):eabh1083. doi: 10.1126/scisignal.abh1083. Epub 2023 Jan 17. Sci Signal. 2023. PMID: 36649377
29 results