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Page 1
Toxic Small Alarmone Synthetase FaRel2 inhibits translation by pyrophosphorylating tRNAGly and tRNAThr.
Kurata T, Takegawa M, Ohira T, Syroegin EA, Atkinson GC, Johansson MJO, Polikanov YS, Garcia-Pino A, Suzuki T, Hauryliuk V. Kurata T, et al. Among authors: syroegin ea. bioRxiv [Preprint]. 2024 Jul 5:2024.07.05.602228. doi: 10.1101/2024.07.05.602228. bioRxiv. 2024. Update in: Sci Adv. 2024 Nov 15;10(46):eadr9624. doi: 10.1126/sciadv.adr9624 PMID: 39005314 Free PMC article. Updated. Preprint.
Rationally Designed Pooled CRISPRi-Seq Uncovers an Inhibitor of Bacterial Peptidyl-tRNA Hydrolase.
Rahman ASMZ, Syroegin EA, Novomisky Nechcoff J, Devarajan A, Polikanov YS, Cardona ST. Rahman ASMZ, et al. Among authors: syroegin ea. bioRxiv [Preprint]. 2024 Jun 29:2024.05.02.592284. doi: 10.1101/2024.05.02.592284. bioRxiv. 2024. Update in: Cell Rep. 2024 Nov 26;43(11):114967. doi: 10.1016/j.celrep.2024.114967 PMID: 38979387 Free PMC article. Updated. Preprint.
An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance.
Wu KJY, Tresco BIC, Ramkissoon A, Aleksandrova EV, Syroegin EA, See DNY, Liow P, Dittemore GA, Yu M, Testolin G, Mitcheltree MJ, Liu RY, Svetlov MS, Polikanov YS, Myers AG. Wu KJY, et al. Among authors: syroegin ea. Science. 2024 Feb 16;383(6684):721-726. doi: 10.1126/science.adk8013. Epub 2024 Feb 15. Science. 2024. PMID: 38359125 Free PMC article.
Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it.
Aleksandrova EV, Wu KJY, Tresco BIC, Syroegin EA, Killeavy EE, Balasanyants SM, Svetlov MS, Gregory ST, Atkinson GC, Myers AG, Polikanov YS. Aleksandrova EV, et al. Among authors: syroegin ea. Nat Chem Biol. 2024 Jul;20(7):867-876. doi: 10.1038/s41589-023-01525-w. Epub 2024 Jan 18. Nat Chem Biol. 2024. PMID: 38238495
Structural basis of Cfr-mediated antimicrobial resistance and mechanisms for its evasion.
Aleksandrova EV, Wu KJY, Tresco BIC, Syroegin EA, Killeavy EE, Balasanyants SM, Svetlov MS, Gregory ST, Atkinson GC, Myers AG, Polikanov YS. Aleksandrova EV, et al. Among authors: syroegin ea. bioRxiv [Preprint]. 2023 Sep 28:2023.09.27.559749. doi: 10.1101/2023.09.27.559749. bioRxiv. 2023. Update in: Nat Chem Biol. 2024 Jul;20(7):867-876. doi: 10.1038/s41589-023-01525-w PMID: 37808676 Free PMC article. Updated. Preprint.
Practical Synthesis of N-Formylmethionylated Peptidyl-tRNA Mimics.
Thaler J, Syroegin EA, Breuker K, Polikanov YS, Micura R. Thaler J, et al. Among authors: syroegin ea. ACS Chem Biol. 2023 Oct 20;18(10):2233-2239. doi: 10.1021/acschembio.3c00237. Epub 2023 Jul 11. ACS Chem Biol. 2023. PMID: 37433044 Free PMC article.
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