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The extended recovery ring-stage survival assay is a scalable alternative for artemisinin susceptibility phenotyping of fresh Plasmodium falciparum isolates.
Okitwi M, Shoue DA, Checkley LA, Orena S, Ceja FG, Taremwa Y, Tumwebaze PK, Katairo T, Byaruhanga O, Sievert MA, Garg S, Kreutzfeld OK, Legac J, Bailey JA, Nsobya SL, Conrad MD, Rosenthal PJ, Ferdig MT, Cooper RA. Okitwi M, et al. Among authors: legac j. Antimicrob Agents Chemother. 2024 Dec 5;68(12):e0118324. doi: 10.1128/aac.01183-24. Epub 2024 Nov 15. Antimicrob Agents Chemother. 2024. PMID: 39545737
Ex vivo susceptibilities to ganaplacide and diversity in potential resistance mediators in Ugandan Plasmodium falciparum isolates.
Kreutzfeld O, Orena S, Okitwi M, Tumwebaze PK, Byaruhanga O, Katairo T, Conrad MD, Legac J, Garg S, Crudale R, Aydemir O, Giesbrecht D, Nsobya SL, Blasco B, Duffey M, Rouillier M, Bailey JA, Cooper RA, Rosenthal PJ. Kreutzfeld O, et al. Among authors: legac j. Antimicrob Agents Chemother. 2024 Sep 4;68(9):e0046624. doi: 10.1128/aac.00466-24. Epub 2024 Aug 13. Antimicrob Agents Chemother. 2024. PMID: 39136468
Ex vivo drug susceptibility and resistance mediating genetic polymorphisms of Plasmodium falciparum in Bobo-Dioulasso, Burkina Faso.
Somé AF, Conrad MD, Kabré Z, Fofana A, Yerbanga RS, Bazié T, Neya C, Somé M, Kagambega TJ, Legac J, Garg S, Bailey JA, Ouédraogo J-B, Rosenthal PJ, Cooper RA. Somé AF, et al. Among authors: legac j. Antimicrob Agents Chemother. 2024 Apr 3;68(4):e0153423. doi: 10.1128/aac.01534-23. Epub 2024 Feb 27. Antimicrob Agents Chemother. 2024. PMID: 38411062 Free PMC article.
Determination of sulfadoxine and pyrimethamine in microvolume human plasma using ultra high performance liquid chromatography-tandam mass spectrometry.
Sok V, Marzan F, Roh M, Guo K, Legac J, Mwebaza N, Dorsey G, Rosenthal PJ, Aweeka FT, Huang L. Sok V, et al. Among authors: legac j. J Chromatogr B Analyt Technol Biomed Life Sci. 2024 Feb 15;1234:124030. doi: 10.1016/j.jchromb.2024.124030. Epub 2024 Jan 24. J Chromatogr B Analyt Technol Biomed Life Sci. 2024. PMID: 38309043
Naphthyl bearing 1,3,4-thiadiazoleacetamides targeting the parasitic folate pathway as anti-infectious agents: in silico, synthesis, and biological approach.
Pal K, Lala S, Agarwal P, Patel TS, Legac J, Rahman MA, Ahmedi S, Shahid N, Singh S, Kumari K, Madhav H, Sen A, Manzoor N, Dixit BC, Van Zyl R, Rosenthal PJ, Hoda N. Pal K, et al. Among authors: legac j. RSC Med Chem. 2023 Nov 21;14(12):2768-2781. doi: 10.1039/d3md00423f. eCollection 2023 Dec 13. RSC Med Chem. 2023. PMID: 38107179 Free PMC article.
Evolution of Partial Resistance to Artemisinins in Malaria Parasites in Uganda.
Conrad MD, Asua V, Garg S, Giesbrecht D, Niaré K, Smith S, Namuganga JF, Katairo T, Legac J, Crudale RM, Tumwebaze PK, Nsobya SL, Cooper RA, Kamya MR, Dorsey G, Bailey JA, Rosenthal PJ. Conrad MD, et al. Among authors: legac j. N Engl J Med. 2023 Aug 24;389(8):722-732. doi: 10.1056/NEJMoa2211803. N Engl J Med. 2023. PMID: 37611122 Free PMC article.
Influence of amino acid size at the P3 position of N-Cbz-tripeptide Michael acceptors targeting falcipain-2 and rhodesain for the treatment of malaria and human african trypanosomiasis.
Previti S, Ettari R, Di Chio C, Legac J, Bogacz M, Zimmer C, Schirmeister T, Rosenthal PJ, Zappalà M. Previti S, et al. Among authors: legac j. Bioorg Chem. 2023 Aug;137:106587. doi: 10.1016/j.bioorg.2023.106587. Epub 2023 May 4. Bioorg Chem. 2023. PMID: 37163812 Free article.
57 results