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An allosteric inhibitor of RhoGAP class-IX myosins suppresses the metastatic features of cancer cells.
Kyriazi D, Voth L, Bader A, Ewert W, Gerlach J, Elfrink K, Franz P, Tsap MI, Schirmer B, Damiano-Guercio J, Hartmann FK, Plenge M, Salari A, Schöttelndreier D, Strienke K, Bresch N, Salinas C, Gutzeit HO, Schaumann N, Hussein K, Bähre H, Brüsch I, Claus P, Neumann D, Taft MH, Shcherbata HR, Ngezahayo A, Bähler M, Amiri M, Knölker HJ, Preller M, Tsiavaliaris G. Kyriazi D, et al. Among authors: damiano guercio j. Nat Commun. 2024 Nov 16;15(1):9947. doi: 10.1038/s41467-024-54181-6. Nat Commun. 2024. PMID: 39550360 Free PMC article.
Functional integrity of the contractile actin cortex is safeguarded by multiple Diaphanous-related formins.
Litschko C, Brühmann S, Csiszár A, Stephan T, Dimchev V, Damiano-Guercio J, Junemann A, Körber S, Winterhoff M, Nordholz B, Ramalingam N, Peckham M, Rottner K, Merkel R, Faix J. Litschko C, et al. Among authors: damiano guercio j. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3594-3603. doi: 10.1073/pnas.1821638116. Epub 2019 Feb 11. Proc Natl Acad Sci U S A. 2019. PMID: 30808751 Free PMC article.