Smith JL - Search Results

1

Structure of a Putative Terminal Amidation Domain in Natural Product Biosynthesis.

Rankin MR, Khare D, Gerwick L, Sherman DH, Gerwick WH, Smith JL. Rankin MR, et al. Among authors: smith jl. bioRxiv [Preprint]. 2024 Oct 28:2024.10.28.620694. doi: 10.1101/2024.10.28.620694. bioRxiv. 2024. PMID: 39554124 Free PMC article. Preprint.

2

Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis.

Whicher JR, Smaga SS, Hansen DA, Brown WC, Gerwick WH, Sherman DH, Smith JL. Whicher JR, et al. Among authors: smith jl. Chem Biol. 2013 Nov 21;20(11):1340-51. doi: 10.1016/j.chembiol.2013.09.015. Epub 2013 Oct 31. Chem Biol. 2013. PMID: 24183970 Free PMC article.

3

Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation.

McCullough TM, Choudhary V, Akey DL, Skiba MA, Bernard SM, Kittendorf JD, Schmidt JJ, Sherman DH, Smith JL. McCullough TM, et al. Among authors: smith jl. bioRxiv [Preprint]. 2024 Jun 20:2024.06.20.599880. doi: 10.1101/2024.06.20.599880. bioRxiv. 2024. PMID: 38948807 Free PMC article. Preprint.

4

Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase.

Gehret JJ, Gu L, Gerwick WH, Wipf P, Sherman DH, Smith JL. Gehret JJ, et al. Among authors: smith jl. J Biol Chem. 2011 Apr 22;286(16):14445-54. doi: 10.1074/jbc.M110.214635. Epub 2011 Feb 27. J Biol Chem. 2011. PMID: 21357626 Free PMC article.

5

Ketoreductase Domain Dysfunction Expands Chemodiversity: Malyngamide Biosynthesis in the Cyanobacterium Okeania hirsuta.

Moss NA, Leão T, Rankin MR, McCullough TM, Qu P, Korobeynikov A, Smith JL, Gerwick L, Gerwick WH. Moss NA, et al. Among authors: smith jl. ACS Chem Biol. 2018 Dec 21;13(12):3385-3395. doi: 10.1021/acschembio.8b00910. Epub 2018 Dec 3. ACS Chem Biol. 2018. PMID: 30444349 Free PMC article.

6

Clearing the skies over modular polyketide synthases.

Sherman DH, Smith JL. Sherman DH, et al. Among authors: smith jl. ACS Chem Biol. 2006 Sep 19;1(8):505-9. doi: 10.1021/cb600376r. ACS Chem Biol. 2006. PMID: 17168537

7

Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase.

Skiba MA, Sikkema AP, Fiers WD, Gerwick WH, Sherman DH, Aldrich CC, Smith JL. Skiba MA, et al. Among authors: smith jl. ACS Chem Biol. 2016 Dec 16;11(12):3319-3327. doi: 10.1021/acschembio.6b00759. Epub 2016 Oct 18. ACS Chem Biol. 2016. PMID: 27723289 Free PMC article.

8

A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit.

Skiba MA, Sikkema AP, Moss NA, Tran CL, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL. Skiba MA, et al. Among authors: smith jl. ACS Chem Biol. 2017 Dec 15;12(12):3039-3048. doi: 10.1021/acschembio.7b00746. Epub 2017 Nov 14. ACS Chem Biol. 2017. PMID: 29096064 Free PMC article.

9

Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module.

Skiba MA, Sikkema AP, Moss NA, Lowell AN, Su M, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL. Skiba MA, et al. Among authors: smith jl. ACS Chem Biol. 2018 Jun 15;13(6):1640-1650. doi: 10.1021/acschembio.8b00252. Epub 2018 May 8. ACS Chem Biol. 2018. PMID: 29701944 Free PMC article.

10

Repurposing the GNAT Fold in the Initiation of Polyketide Biosynthesis.

Skiba MA, Tran CL, Dan Q, Sikkema AP, Klaver Z, Gerwick WH, Sherman DH, Smith JL. Skiba MA, et al. Among authors: smith jl. Structure. 2020 Jan 7;28(1):63-74.e4. doi: 10.1016/j.str.2019.11.004. Epub 2019 Nov 27. Structure. 2020. PMID: 31785925 Free PMC article.

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