Zhang SQ - Search Results

1

Lysine-Targeted Covalent Inhibitors of PI3Kδ Synthesis and Screening by In Situ Interaction Upgradation.

Yuan B, Feng Y, Ma M, Duan W, Wu Y, Liu J, Zhao HY, Yang Z, Zhang SQ, Xin M. Yuan B, et al. Among authors: zhang sq. J Med Chem. 2024 Nov 28;67(22):20076-20099. doi: 10.1021/acs.jmedchem.4c01284. Epub 2024 Nov 19. J Med Chem. 2024. PMID: 39561981

2

Design, synthesis and antiproliferative activity evaluation of m-(4-morpholinyl-1,3,5-triazin-2-yl)benzamides in vitro.

Wang XM, Xu J, Xin MH, Lu SM, Zhang SQ. Wang XM, et al. Among authors: zhang sq. Bioorg Med Chem Lett. 2015 Apr 15;25(8):1730-1735. doi: 10.1016/j.bmcl.2015.02.067. Epub 2015 Mar 6. Bioorg Med Chem Lett. 2015. PMID: 25765909

3

Synthesis and antitumor activities evaluation of m-(4-morpholinoquinazolin-2-yl)benzamides in vitro and in vivo.

Wang XM, Xin MH, Xu J, Kang BR, Li Y, Lu SM, Zhang SQ. Wang XM, et al. Among authors: zhang sq. Eur J Med Chem. 2015;96:382-95. doi: 10.1016/j.ejmech.2015.04.037. Epub 2015 Apr 17. Eur J Med Chem. 2015. PMID: 25911625

4

Synthesis and anticancer effects evaluation of 1-alkyl-3-(6-(2-methoxy-3-sulfonylaminopyridin-5-yl)benzo[d]thiazol-2-yl)urea as anticancer agents with low toxicity.

Xie XX, Li H, Wang J, Mao S, Xin MH, Lu SM, Mei QB, Zhang SQ. Xie XX, et al. Among authors: zhang sq. Bioorg Med Chem. 2015 Oct 1;23(19):6477-85. doi: 10.1016/j.bmc.2015.08.013. Epub 2015 Aug 19. Bioorg Med Chem. 2015. PMID: 26321603

5

Synthesis and antitumor activity evaluation of PI3K inhibitors containing 3-substituted quinazolin-4(3H)-one moiety.

Zhang H, Xin MH, Xie XX, Mao S, Zuo SJ, Lu SM, Zhang SQ. Zhang H, et al. Among authors: zhang sq. Bioorg Med Chem. 2015 Dec 15;23(24):7765-76. doi: 10.1016/j.bmc.2015.11.027. Epub 2015 Nov 22. Bioorg Med Chem. 2015. PMID: 26652969

6

Synthesis and antitumor activity evaluation of 4,6-disubstituted quinazoline derivatives as novel PI3K inhibitors.

Hei YY, Xin M, Zhang H, Xie XX, Mao S, Zhang SQ. Hei YY, et al. Among authors: zhang sq, zhang h. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4408-4413. doi: 10.1016/j.bmcl.2016.08.015. Epub 2016 Aug 8. Bioorg Med Chem Lett. 2016. PMID: 27544401

7

Design and synthesis of novel 6-aryl substituted 4-anilinequinazoline derivatives as potential PI3Kδ inhibitors.

Xin M, Hei YY, Zhang H, Shen Y, Zhang SQ. Xin M, et al. Among authors: zhang sq, zhang h. Bioorg Med Chem Lett. 2017 May 1;27(9):1972-1977. doi: 10.1016/j.bmcl.2017.03.020. Epub 2017 Mar 11. Bioorg Med Chem Lett. 2017. PMID: 28325601

8

Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs.

Zhang H, Wang J, Shen Y, Wang HY, Duan WM, Zhao HY, Hei YY, Xin M, Cao YX, Zhang SQ. Zhang H, et al. Among authors: zhang sq. Eur J Med Chem. 2018 Mar 25;148:221-237. doi: 10.1016/j.ejmech.2018.02.051. Epub 2018 Feb 16. Eur J Med Chem. 2018. PMID: 29466773

9

Novel 6-aryl substituted 4-pyrrolidineaminoquinazoline derivatives as potent phosphoinositide 3-kinase delta (PI3Kδ) inhibitors.

Xin M, Duan W, Feng Y, Hei YY, Zhang H, Shen Y, Zhao HY, Mao S, Zhang SQ. Xin M, et al. Among authors: zhang sq, zhang h. Bioorg Med Chem. 2018 May 1;26(8):2028-2040. doi: 10.1016/j.bmc.2018.03.002. Epub 2018 Mar 2. Bioorg Med Chem. 2018. PMID: 29534936

10

Introduction of pyrrolidineoxy or piperidineamino group at the 4-position of quinazoline leading to novel quinazoline-based phosphoinositide 3-kinase delta (PI3Kδ) inhibitors.

Xin M, Duan W, Feng Y, Hei YY, Zhang H, Shen Y, Zhao HY, Mao S, Zhang SQ. Xin M, et al. Among authors: zhang sq, zhang h. J Enzyme Inhib Med Chem. 2018 Dec;33(1):651-656. doi: 10.1080/14756366.2018.1444608. J Enzyme Inhib Med Chem. 2018. PMID: 29536777 Free PMC article.

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