Zhao HY - Search Results

1

Lysine-Targeted Covalent Inhibitors of PI3Kδ Synthesis and Screening by In Situ Interaction Upgradation.

Yuan B, Feng Y, Ma M, Duan W, Wu Y, Liu J, Zhao HY, Yang Z, Zhang SQ, Xin M. Yuan B, et al. Among authors: zhao hy. J Med Chem. 2024 Nov 28;67(22):20076-20099. doi: 10.1021/acs.jmedchem.4c01284. Epub 2024 Nov 19. J Med Chem. 2024. PMID: 39561981

2

Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs.

Zhang H, Wang J, Shen Y, Wang HY, Duan WM, Zhao HY, Hei YY, Xin M, Cao YX, Zhang SQ. Zhang H, et al. Among authors: zhao hy. Eur J Med Chem. 2018 Mar 25;148:221-237. doi: 10.1016/j.ejmech.2018.02.051. Epub 2018 Feb 16. Eur J Med Chem. 2018. PMID: 29466773

3

Novel 6-aryl substituted 4-pyrrolidineaminoquinazoline derivatives as potent phosphoinositide 3-kinase delta (PI3Kδ) inhibitors.

Xin M, Duan W, Feng Y, Hei YY, Zhang H, Shen Y, Zhao HY, Mao S, Zhang SQ. Xin M, et al. Among authors: zhao hy. Bioorg Med Chem. 2018 May 1;26(8):2028-2040. doi: 10.1016/j.bmc.2018.03.002. Epub 2018 Mar 2. Bioorg Med Chem. 2018. PMID: 29534936

4

Introduction of pyrrolidineoxy or piperidineamino group at the 4-position of quinazoline leading to novel quinazoline-based phosphoinositide 3-kinase delta (PI3Kδ) inhibitors.

Xin M, Duan W, Feng Y, Hei YY, Zhang H, Shen Y, Zhao HY, Mao S, Zhang SQ. Xin M, et al. Among authors: zhao hy. J Enzyme Inhib Med Chem. 2018 Dec;33(1):651-656. doi: 10.1080/14756366.2018.1444608. J Enzyme Inhib Med Chem. 2018. PMID: 29536777 Free PMC article.

5

Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors.

Hei YY, Shen Y, Wang J, Zhang H, Zhao HY, Xin M, Cao YX, Li Y, Zhang SQ. Hei YY, et al. Among authors: zhao hy. Bioorg Med Chem. 2018 May 1;26(8):2173-2185. doi: 10.1016/j.bmc.2018.03.025. Epub 2018 Mar 16. Bioorg Med Chem. 2018. PMID: 29576272

6

Synthesis and biological evaluation of irreversible EGFR tyrosine kinase inhibitors containing pyrido[3,4-d]pyrimidine scaffold.

Zhang H, Wang J, Zhao HY, Yang XY, Lei H, Xin M, Cao YX, Zhang SQ. Zhang H, et al. Among authors: zhao hy. Bioorg Med Chem. 2018 Jul 23;26(12):3619-3633. doi: 10.1016/j.bmc.2018.05.039. Epub 2018 May 24. Bioorg Med Chem. 2018. PMID: 29853340

7

Discovery of 2-(aminopyrimidin-5-yl)-4-(morpholin-4-yl)-6- substituted triazine as PI3K and BRAF dual inhibitor.

Wang HY, Shen Y, Zhang H, Hei YY, Zhao HY, Xin M, Lu SM, Zhang SQ. Wang HY, et al. Among authors: zhao hy. Future Med Chem. 2018 Oct;10(20):2445-2455. doi: 10.4155/fmc-2018-0145. Epub 2018 Oct 16. Future Med Chem. 2018. PMID: 30325235

8

Discovery of potent epidermal growth factor receptor (EGFR) degraders by proteolysis targeting chimera (PROTAC).

Zhang H, Zhao HY, Xi XX, Liu YJ, Xin M, Mao S, Zhang JJ, Lu AX, Zhang SQ. Zhang H, et al. Among authors: zhao hy. Eur J Med Chem. 2020 Mar 1;189:112061. doi: 10.1016/j.ejmech.2020.112061. Epub 2020 Jan 14. Eur J Med Chem. 2020. PMID: 31951960

9

Discovery of potent small molecule PROTACs targeting mutant EGFR.

Zhao HY, Yang XY, Lei H, Xi XX, Lu SM, Zhang JJ, Xin M, Zhang SQ. Zhao HY, et al. Eur J Med Chem. 2020 Dec 15;208:112781. doi: 10.1016/j.ejmech.2020.112781. Epub 2020 Aug 26. Eur J Med Chem. 2020. PMID: 32883633

10

Recent Progress of Small Molecule Menin-MLL Interaction Inhibitors as Therapeutic Agents for Acute Leukemia.

Lei H, Zhang SQ, Fan S, Bai HR, Zhao HY, Mao S, Xin M. Lei H, et al. Among authors: zhao hy. J Med Chem. 2021 Nov 11;64(21):15519-15533. doi: 10.1021/acs.jmedchem.1c00872. Epub 2021 Nov 2. J Med Chem. 2021. PMID: 34726905 Review.

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