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Repurposing Drugs and Synergistic Combinations as Potential Therapies for Inhibiting SARS-CoV-2 and Coronavirus Replication.
Boulon R, Mazeaud C, Farahani MD, Broquière M, Iddir M, Charpentier T, Anton A, Ayotte Y, Woo S, Lamarre A, Chatel-Chaix L, LaPlante SR. Boulon R, et al. Among authors: chatel chaix l. ACS Pharmacol Transl Sci. 2024 Nov 5;7(12):4043-4055. doi: 10.1021/acsptsci.4c00512. eCollection 2024 Dec 13. ACS Pharmacol Transl Sci. 2024. PMID: 39698276
Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates.
Goethals O, Kaptein SJF, Kesteleyn B, Bonfanti JF, Van Wesenbeeck L, Bardiot D, Verschoor EJ, Verstrepen BE, Fagrouch Z, Putnak JR, Kiemel D, Ackaert O, Straetemans R, Lachau-Durand S, Geluykens P, Crabbe M, Thys K, Stoops B, Lenz O, Tambuyzer L, De Meyer S, Dallmeier K, McCracken MK, Gromowski GD, Rutvisuttinunt W, Jarman RG, Karasavvas N, Touret F, Querat G, de Lamballerie X, Chatel-Chaix L, Milligan GN, Beasley DWC, Bourne N, Barrett ADT, Marchand A, Jonckers THM, Raboisson P, Simmen K, Chaltin P, Bartenschlager R, Bogers WM, Neyts J, Van Loock M. Goethals O, et al. Among authors: chatel chaix l. Nature. 2023 Mar;615(7953):678-686. doi: 10.1038/s41586-023-05790-6. Epub 2023 Mar 15. Nature. 2023. PMID: 36922586 Free PMC article.
N-Phenylpyridine-3-Carboxamide and 6-Acetyl-1H-Indazole Inhibit the RNA Replication Step of the Dengue Virus Life Cycle.
Sow AA, Pahmeier F, Ayotte Y, Anton A, Mazeaud C, Charpentier T, Angelo L, Woo S, Cerikan B, Falzarano D, Abrahamyan L, Lamarre A, Labonté P, Cortese M, Bartenschlager R, LaPlante SR, Chatel-Chaix L. Sow AA, et al. Among authors: chatel chaix l. Antimicrob Agents Chemother. 2023 Feb 16;67(2):e0133122. doi: 10.1128/aac.01331-22. Epub 2023 Jan 26. Antimicrob Agents Chemother. 2023. PMID: 36700643 Free PMC article.
Fragment-Based Phenotypic Lead Discovery To Identify New Drug Seeds That Target Infectious Diseases.
Ayotte Y, Bernet E, Bilodeau F, Cimino M, Gagnon D, Lebughe M, Mistretta M, Ogadinma P, Ouali SL, Sow AA, Chatel-Chaix L, Descoteaux A, Manina G, Richard D, Veyrier F, LaPlante SR. Ayotte Y, et al. Among authors: chatel chaix l. ACS Chem Biol. 2021 Nov 19;16(11):2158-2163. doi: 10.1021/acschembio.1c00657. Epub 2021 Oct 26. ACS Chem Biol. 2021. PMID: 34699722
46 results