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Page 1
The triglyceride-synthesizing enzyme diacylglycerol acyltransferase 2 modulates the formation of the hepatitis C virus replication organelle.
Reichert I, Lee JY, Weber L, Fuh MM, Schlaeger L, Rößler S, Kinast V, Schlienkamp S, Conradi J, Vondran FWR, Pfaender S, Scaturro P, Steinmann E, Bartenschlager R, Pietschmann T, Heeren J, Lauber C, Vieyres G. Reichert I, et al. Among authors: scaturro p. PLoS Pathog. 2024 Sep 6;20(9):e1012509. doi: 10.1371/journal.ppat.1012509. eCollection 2024 Sep. PLoS Pathog. 2024. PMID: 39241103 Free PMC article.
Pan-serotype dengue virus inhibitor JNJ-A07 targets NS4A-2K-NS4B interaction with NS2B/NS3 and blocks replication organelle formation.
Kiemel D, Kroell AH, Denolly S, Haselmann U, Bonfanti JF, Andres JI, Ghosh B, Geluykens P, Kaptein SJF, Wilken L, Scaturro P, Neyts J, Van Loock M, Goethals O, Bartenschlager R. Kiemel D, et al. Among authors: scaturro p. Nat Commun. 2024 Jul 19;15(1):6080. doi: 10.1038/s41467-024-50437-3. Nat Commun. 2024. PMID: 39030239 Free PMC article.
Identification of host dependency factors involved in SARS-CoV-2 replication organelle formation through proteomics and ultrastructural analysis.
Pahmeier F, Lavacca T-M, Goellner S, Neufeldt CJ, Prasad V, Cerikan B, Rajasekharan S, Mizzon G, Haselmann U, Funaya C, Scaturro P, Cortese M, Bartenschlager R. Pahmeier F, et al. Among authors: scaturro p. J Virol. 2023 Nov 30;97(11):e0087823. doi: 10.1128/jvi.00878-23. Epub 2023 Oct 31. J Virol. 2023. PMID: 37905840 Free PMC article.
Dengue virus NS1 secretion is regulated via importin-subunit β1 controlling expression of the chaperone GRp78 and targeted by the clinical drug ivermectin.
Denolly S, Guo H, Martens M, Płaszczyca A, Scaturro P, Prasad V, Kongmanas K, Punyadee N, Songjaeng A, Mairiang D, Pichlmair A, Avirutnan P, Bartenschlager R. Denolly S, et al. Among authors: scaturro p. mBio. 2023 Oct 31;14(5):e0144123. doi: 10.1128/mbio.01441-23. Epub 2023 Sep 13. mBio. 2023. PMID: 37702492 Free PMC article.
Molecular consequences of SARS-CoV-2 liver tropism.
Wanner N, Andrieux G, Badia-I-Mompel P, Edler C, Pfefferle S, Lindenmeyer MT, Schmidt-Lauber C, Czogalla J, Wong MN, Okabayashi Y, Braun F, Lütgehetmann M, Meister E, Lu S, Noriega MLM, Günther T, Grundhoff A, Fischer N, Bräuninger H, Lindner D, Westermann D, Haas F, Roedl K, Kluge S, Addo MM, Huber S, Lohse AW, Reiser J, Ondruschka B, Sperhake JP, Saez-Rodriguez J, Boerries M, Hayek SS, Aepfelbacher M, Scaturro P, Puelles VG, Huber TB. Wanner N, et al. Among authors: scaturro p. Nat Metab. 2022 Mar;4(3):310-319. doi: 10.1038/s42255-022-00552-6. Epub 2022 Mar 28. Nat Metab. 2022. PMID: 35347318 Free PMC article.
NUDT2 initiates viral RNA degradation by removal of 5'-phosphates.
Laudenbach BT, Krey K, Emslander Q, Andersen LL, Reim A, Scaturro P, Mundigl S, Dächert C, Manske K, Moser M, Ludwig J, Wohlleber D, Kröger A, Binder M, Pichlmair A. Laudenbach BT, et al. Among authors: scaturro p. Nat Commun. 2021 Nov 25;12(1):6918. doi: 10.1038/s41467-021-27239-y. Nat Commun. 2021. PMID: 34824277 Free PMC article.
27 results