Rishavy MA - Search Results

1

Cellular and biochemical approaches to define GGCX carboxylation of vitamin K-dependent proteins.

Berkner KL, Hallgren KW, Rishavy MA, Runge KW. Berkner KL, et al. Among authors: rishavy ma. Methods Enzymol. 2024;708:175-205. doi: 10.1016/bs.mie.2024.10.023. Epub 2024 Nov 7. Methods Enzymol. 2024. PMID: 39572139

2

GGCX mutants that impair hemostasis reveal the importance of processivity and full carboxylation to VKD protein function.

Rishavy MA, Hallgren KW, Wilson LA, Hiznay JM, Runge KW, Berkner KL. Rishavy MA, et al. Blood. 2022 Oct 13;140(15):1710-1722. doi: 10.1182/blood.2021014275. Blood. 2022. PMID: 35767717 Free PMC article.

3

Exon 2 skipping eliminates γ-glutamyl carboxylase activity, indicating a partial splicing defect in a patient with vitamin K clotting factor deficiency.

Rishavy MA, Hallgren KW, Zhang H, Runge KW, Berkner KL. Rishavy MA, et al. J Thromb Haemost. 2019 Jul;17(7):1053-1063. doi: 10.1111/jth.14456. Epub 2019 Jun 7. J Thromb Haemost. 2019. PMID: 31009158 Free PMC article.

4

Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase.

Rishavy MA, Hallgren KW, Wilson L, Singh S, Runge KW, Berkner KL. Rishavy MA, et al. Blood. 2018 Jun 21;131(25):2826-2835. doi: 10.1182/blood-2017-09-804666. Epub 2018 Mar 28. Blood. 2018. PMID: 29592891 Free PMC article.

5

VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo.

Lacombe J, Rishavy MA, Berkner KL, Ferron M. Lacombe J, et al. Among authors: rishavy ma. JCI Insight. 2018 Jan 11;3(1):e96501. doi: 10.1172/jci.insight.96501. eCollection 2018 Jan 11. JCI Insight. 2018. PMID: 29321368 Free PMC article.

6

The vitamin K oxidoreductase is a multimer that efficiently reduces vitamin K epoxide to hydroquinone to allow vitamin K-dependent protein carboxylation.

Rishavy MA, Hallgren KW, Wilson LA, Usubalieva A, Runge KW, Berkner KL. Rishavy MA, et al. J Biol Chem. 2013 Nov 1;288(44):31556-66. doi: 10.1074/jbc.M113.497297. Epub 2013 Aug 5. J Biol Chem. 2013. PMID: 23918929 Free PMC article.

7

Vitamin K oxygenation, glutamate carboxylation, and processivity: defining the three critical facets of catalysis by the vitamin K-dependent carboxylase.

Rishavy MA, Berkner KL. Rishavy MA, et al. Adv Nutr. 2012 Mar 1;3(2):135-48. doi: 10.3945/an.111.001719. Adv Nutr. 2012. PMID: 22516721 Free PMC article. Review.

8

The vitamin K-dependent carboxylase generates γ-carboxylated glutamates by using CO2 to facilitate glutamate deprotonation in a concerted mechanism that drives catalysis.

Rishavy MA, Hallgren KW, Berkner KL. Rishavy MA, et al. J Biol Chem. 2011 Dec 30;286(52):44821-32. doi: 10.1074/jbc.M111.249177. Epub 2011 Sep 6. J Biol Chem. 2011. PMID: 21896484 Free PMC article.

9

Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation.

Rishavy MA, Usubalieva A, Hallgren KW, Berkner KL. Rishavy MA, et al. J Biol Chem. 2011 Mar 4;286(9):7267-78. doi: 10.1074/jbc.M110.172213. Epub 2010 Oct 26. J Biol Chem. 2011. PMID: 20978134 Free PMC article.

10

Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes.

Li Q, Grange DK, Armstrong NL, Whelan AJ, Hurley MY, Rishavy MA, Hallgren KW, Berkner KL, Schurgers LJ, Jiang Q, Uitto J. Li Q, et al. Among authors: rishavy ma. J Invest Dermatol. 2009 Mar;129(3):553-63. doi: 10.1038/jid.2008.271. Epub 2008 Sep 18. J Invest Dermatol. 2009. PMID: 18800149 Free PMC article.

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