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Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability.
Smirnov P, Przybilla MJ, Simovic-Lorenz M, Parra RG, Susak H, Ratnaparkhe M, Wong JK, Körber V, Mallm JP, Philippos G, Sill M, Kolb T, Kumar R, Casiraghi N, Okonechnikov K, Ghasemi DR, Maaß KK, Pajtler KW, Jauch A, Korshunov A, Höfer T, Zapatka M, Pfister SM, Huber W, Stegle O, Ernst A. Smirnov P, et al. Among authors: kolb t. Nat Commun. 2024 Nov 23;15(1):10183. doi: 10.1038/s41467-024-54547-w. Nat Commun. 2024. PMID: 39580568 Free PMC article.
Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors.
Ratnaparkhe M, Wong JKL, Wei PC, Hlevnjak M, Kolb T, Simovic M, Haag D, Paul Y, Devens F, Northcott P, Jones DTW, Kool M, Jauch A, Pastorczak A, Mlynarski W, Korshunov A, Kumar R, Downing SM, Pfister SM, Zapatka M, McKinnon PJ, Alt FW, Lichter P, Ernst A. Ratnaparkhe M, et al. Among authors: kolb t. Nat Commun. 2018 Nov 12;9(1):4760. doi: 10.1038/s41467-018-06925-4. Nat Commun. 2018. PMID: 30420702 Free PMC article.
Genomic profiling of Acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis.
Ratnaparkhe M, Hlevnjak M, Kolb T, Jauch A, Maass KK, Devens F, Rode A, Hovestadt V, Korshunov A, Pastorczak A, Mlynarski W, Sungalee S, Korbel J, Hoell J, Fischer U, Milde T, Kramm C, Nathrath M, Chrzanowska K, Tausch E, Takagi M, Taga T, Constantini S, Loeffen J, Meijerink J, Zielen S, Gohring G, Schlegelberger B, Maass E, Siebert R, Kunz J, Kulozik AE, Worst B, Jones DT, Pfister SM, Zapatka M, Lichter P, Ernst A. Ratnaparkhe M, et al. Among authors: kolb t. Leukemia. 2017 Oct;31(10):2048-2056. doi: 10.1038/leu.2017.55. Epub 2017 Feb 15. Leukemia. 2017. PMID: 28196983
A synergistic interaction between HDAC- and PARP inhibitors in childhood tumors with chromothripsis.
Khalid U, Simovic M, Hammann LA, Iskar M, Wong JKL, Kumar R, Jugold M, Sill M, Bolkestein M, Kolb T, Hergt M, Devens F, Ecker J, Kool M, Milde T, Westermann F, Benner A, Lewis J, Dietrich S, Pfister SM, Lichter P, Zapatka M, Ernst A. Khalid U, et al. Among authors: kolb t. Int J Cancer. 2022 Aug 15;151(4):590-606. doi: 10.1002/ijc.34027. Epub 2022 Apr 28. Int J Cancer. 2022. PMID: 35411591
The age of adult pilocytic astrocytoma cells.
Voronina N, Aichmüller C, Kolb T, Korshunov A, Ryzhova M, Barnholtz-Sloan J, Cioffi G, Sill M, von Deimling A, Pfister SM, Gronych J, Jones DTW, Frisén J, Zapatka M, Ernst A. Voronina N, et al. Among authors: kolb t. Oncogene. 2021 Apr;40(16):2830-2841. doi: 10.1038/s41388-021-01738-0. Epub 2021 Mar 17. Oncogene. 2021. PMID: 33731860 Free PMC article.
199 results