The parmodulin NRD-21 is an allosteric inhibitor of PAR1 Gq signaling with improved anti-inflammatory activity and stability.
Gandhi DM, Rosas R Jr, Greve E, Kentala K, D-R Diby N, Snyder VA, Stephans A, Yeung THW, Subramaniam S, DiMilo E, Kurtenbach KE, Arnold LA, Weiler H, Dockendorff C.
Gandhi DM, et al. Among authors: greve e.
Bioorg Med Chem. 2019 Sep 1;27(17):3788-3796. doi: 10.1016/j.bmc.2019.06.043. Epub 2019 Jun 29.
Bioorg Med Chem. 2019.
PMID: 31320211
Free PMC article.