Kim TW - Search Results

1

A Combined Fertility and Developmental Toxicity Study with an Antisense Oligonucleotide Targeting Murine Apolipoprotein C-III mRNA in Mice.

Jeong JS, Rastogi A, Kim TW, Henry S, Hoffmaster CM, Kim SY, Kim W, Lee SY, Park JD, Wi IS, Yu WJ, Lee J. Jeong JS, et al. Among authors: kim w, kim tw, kim sy. Nucleic Acid Ther. 2024 Dec;34(6):285-294. doi: 10.1089/nat.2024.0057. Epub 2024 Nov 25. Nucleic Acid Ther. 2024. PMID: 39585752

2

Impurity Qualification Toxicology Study for a 2'-O-Methoxyethyl-Modified Antisense Inhibitor in Mice.

Kim TW, Papagiannis C, Capaldi D, McPherson AK, Mahdi F, Luu N, Rodriguez AA, Hoffmaster C, Serota D, Henry SP. Kim TW, et al. Nucleic Acid Ther. 2020 Feb;30(1):14-21. doi: 10.1089/nat.2019.0780. Epub 2019 Nov 5. Nucleic Acid Ther. 2020. PMID: 31687889

3

Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys.

Burel SA, Han SR, Lee HS, Norris DA, Lee BS, Machemer T, Park SY, Zhou T, He G, Kim Y, MacLeod AR, Monia BP, Lio S, Kim TW, Henry SP. Burel SA, et al. Among authors: kim tw, kim y. Nucleic Acid Ther. 2013 Jun;23(3):213-27. doi: 10.1089/nat.2013.0422. Nucleic Acid Ther. 2013. PMID: 23692080

4

Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys.

Yu RZ, Gunawan R, Post N, Zanardi T, Hall S, Burkey J, Kim TW, Graham MJ, Prakash TP, Seth PP, Swayze EE, Geary RS, Henry SP, Wang Y. Yu RZ, et al. Among authors: kim tw. Nucleic Acid Ther. 2016 Dec;26(6):372-380. doi: 10.1089/nat.2016.0623. Epub 2016 Aug 8. Nucleic Acid Ther. 2016. PMID: 27500733

5

Chronic Toxicity Assessment of 2'-O-Methoxyethyl Antisense Oligonucleotides in Mice.

Zanardi TA, Kim TW, Shen L, Serota D, Papagiannis C, Park SY, Kim Y, Henry SP. Zanardi TA, et al. Among authors: kim tw, kim y. Nucleic Acid Ther. 2018 Aug;28(4):233-241. doi: 10.1089/nat.2017.0706. Epub 2018 Apr 30. Nucleic Acid Ther. 2018. PMID: 29708844

6

Comparison of the Class Effects of Antisense Oligonucleotides in CByB6F1-Tg(HRAS)2Jic and CD-1 Mice.

Kim TW, Papagiannis CN, Zwick LS, Engelhardt JA, Hoffmaster CM, Post NM, Matson JE, Hsiao JA, Burel SA, Henry SP. Kim TW, et al. Toxicol Pathol. 2019 Jan;47(1):82-92. doi: 10.1177/0192623318813143. Epub 2018 Dec 25. Toxicol Pathol. 2019. PMID: 30585133

7

Immunogenicity Assessment of Inotersen, a 2'-O-(2-Methoxyethyl) Antisense Oligonucleotide in Animals and Humans: Effect on Pharmacokinetics, Pharmacodynamics, and Safety.

Yu RZ, Wang Y, Norris DA, Kim TW, Narayanan P, Geary RS, Monia BP, Henry SP. Yu RZ, et al. Among authors: kim tw. Nucleic Acid Ther. 2020 Oct;30(5):265-275. doi: 10.1089/nat.2020.0867. Epub 2020 Aug 19. Nucleic Acid Ther. 2020. PMID: 32833564 Clinical Trial.

8

Carcinogenicity assessment of inotersen in Tg.rasH2 mice and Sprague-Dawley rats: Implications for 2'-MOE antisense oligonucleotides.

Kim TW, Papagiannis CN, Zwick LS, Snyder P, Engelhardt JA, Yu RZ, Hoffmaster CM, Rastogi A, Henry SP. Kim TW, et al. Regul Toxicol Pharmacol. 2025 Jan;155:105743. doi: 10.1016/j.yrtph.2024.105743. Epub 2024 Nov 22. Regul Toxicol Pharmacol. 2025. PMID: 39580013 Free article.

9

Antisense oligonucleotides on neurobehavior, respiratory, and cardiovascular function, and hERG channel current studies.

Kim TW, Kim KS, Seo JW, Park SY, Henry SP. Kim TW, et al. Among authors: kim ks. J Pharmacol Toxicol Methods. 2014 Jan-Feb;69(1):49-60. doi: 10.1016/j.vascn.2013.10.005. Epub 2013 Nov 8. J Pharmacol Toxicol Methods. 2014. PMID: 24211663 Free article.

10

Predictive dose-based estimation of systemic exposure multiples in mouse and monkey relative to human for antisense oligonucleotides with 2'-o-(2-methoxyethyl) modifications.

Yu RZ, Grundy JS, Henry SP, Kim TW, Norris DA, Burkey J, Wang Y, Vick A, Geary RS. Yu RZ, et al. Among authors: kim tw. Mol Ther Nucleic Acids. 2015 Jan 20;4(1):e218. doi: 10.1038/mtna.2014.69. Mol Ther Nucleic Acids. 2015. PMID: 25602582 Free PMC article.

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