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Page 1
Catabolism of extracellular glutathione supplies amino acids to support tumor growth.
Hecht F, Zocchi M, Tuttle ET, Ward NP, Smith B, Kang YP, Cazarin J, Soares ZG, Ozgurses ME, Zhao H, Sheehan C, Alimohammadi F, Munger LD, Trivedi D, Asantewaa G, Blick-Nitko SK, Zoeller JJ, Chen Y, Vasiliou V, Turner BM, Muir A, Coloff JL, Munger J, DeNicola GM, Harris IS. Hecht F, et al. Among authors: denicola gm. bioRxiv [Preprint]. 2024 Oct 13:2024.10.10.617667. doi: 10.1101/2024.10.10.617667. bioRxiv. 2024. PMID: 39416022 Free PMC article. Preprint.
Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy.
Rawat V, DeLear P, Prashanth P, Ozgurses ME, Tebeje A, Burns PA, Conger KO, Solís C, Hasnain Y, Novikova A, Endress JE, González-Sánchez P, Dong W, Stephanopoulos G, DeNicola GM, Harris IS, Sept D, Mason FM, Coloff JL. Rawat V, et al. Among authors: denicola gm. JCI Insight. 2024 May 30;9(13):e174329. doi: 10.1172/jci.insight.174329. JCI Insight. 2024. PMID: 38815134 Free PMC article.
ASCT2 is a major contributor to serine uptake in cancer cells.
Conger KO, Chidley C, Ozgurses ME, Zhao H, Kim Y, Semina SE, Burns P, Rawat V, Lietuvninkas L, Sheldon R, Ben-Sahra I, Frasor J, Sorger PK, DeNicola GM, Coloff JL. Conger KO, et al. Among authors: denicola gm. Cell Rep. 2024 Aug 27;43(8):114552. doi: 10.1016/j.celrep.2024.114552. Epub 2024 Jul 27. Cell Rep. 2024. PMID: 39068660 Free PMC article.
Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography.
Greenwood HE, Barber AR, Edwards RS, Tyrrell WE, George ME, Dos Santos SN, Baark F, Tanc M, Khalil E, Falzone A, Ward NP, DeBlasi JM, Torrente L, Soni PN, Pearce DR, Firth G, Smith LM, Vilhelmsson Timmermand O, Huebner A, Swanton C, Hynds RE, DeNicola GM, Witney TH. Greenwood HE, et al. Among authors: denicola gm. Nat Commun. 2024 Dec 17;15(1):10484. doi: 10.1038/s41467-024-54852-4. Nat Commun. 2024. PMID: 39690148 Free PMC article.
Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression.
Asantewaa G, Tuttle ET, Ward NP, Kang YP, Kim Y, Kavanagh ME, Girnius N, Chen Y, Rodriguez K, Hecht F, Zocchi M, Smorodintsev-Schiller L, Scales TQ, Taylor K, Alimohammadi F, Duncan RP, Sechrist ZR, Agostini-Vulaj D, Schafer XL, Chang H, Smith ZR, O'Connor TN, Whelan S, Selfors LM, Crowdis J, Gray GK, Bronson RT, Brenner D, Rufini A, Dirksen RT, Hezel AF, Huber AR, Munger J, Cravatt BF, Vasiliou V, Cole CL, DeNicola GM, Harris IS. Asantewaa G, et al. Among authors: denicola gm. Nat Commun. 2024 Jul 21;15(1):6152. doi: 10.1038/s41467-024-50454-2. Nat Commun. 2024. PMID: 39034312 Free PMC article.
A tandem activity-based sensing and labeling strategy reveals antioxidant response element regulation of labile iron pools.
Pezacki AT, Gonciarz RL, Okamura T, Matier CD, Torrente L, Cheng K, Miller SG, Ralle M, Ward NP, DeNicola GM, Renslo AR, Chang CJ. Pezacki AT, et al. Among authors: denicola gm. Proc Natl Acad Sci U S A. 2024 Jul 9;121(28):e2401579121. doi: 10.1073/pnas.2401579121. Epub 2024 Jul 5. Proc Natl Acad Sci U S A. 2024. PMID: 38968123 Free PMC article.
79 results