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Staggered immunization with mRNA vaccines encoding SARS-CoV-2 polymerase or spike antigens broadens the T cell epitope repertoire.
Abt ER, Lam AK, Noguchi M, Rashid K, McLaughlin J, Teng PL, Tran W, Cheng D, Nesterenko PA, Mao Z, Creech AL, Burton Sojo G, Jeyachandran AV, Tam YK, Henley JE, Comai L, Pardi N, Arumugaswami V, Witte ON, Radu CG, Wu TT. Abt ER, et al. Among authors: tam yk. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2406332121. doi: 10.1073/pnas.2406332121. Epub 2024 Nov 26. Proc Natl Acad Sci U S A. 2024. PMID: 39589869 Free PMC article.
Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination.
Pardi N, Hogan MJ, Pelc RS, Muramatsu H, Andersen H, DeMaso CR, Dowd KA, Sutherland LL, Scearce RM, Parks R, Wagner W, Granados A, Greenhouse J, Walker M, Willis E, Yu JS, McGee CE, Sempowski GD, Mui BL, Tam YK, Huang YJ, Vanlandingham D, Holmes VM, Balachandran H, Sahu S, Lifton M, Higgs S, Hensley SE, Madden TD, Hope MJ, Karikó K, Santra S, Graham BS, Lewis MG, Pierson TC, Haynes BF, Weissman D. Pardi N, et al. Among authors: tam yk. Nature. 2017 Mar 9;543(7644):248-251. doi: 10.1038/nature21428. Epub 2017 Feb 2. Nature. 2017. PMID: 28151488 Free PMC article.
Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses.
Pardi N, Hogan MJ, Naradikian MS, Parkhouse K, Cain DW, Jones L, Moody MA, Verkerke HP, Myles A, Willis E, LaBranche CC, Montefiori DC, Lobby JL, Saunders KO, Liao HX, Korber BT, Sutherland LL, Scearce RM, Hraber PT, Tombácz I, Muramatsu H, Ni H, Balikov DA, Li C, Mui BL, Tam YK, Krammer F, Karikó K, Polacino P, Eisenlohr LC, Madden TD, Hope MJ, Lewis MG, Lee KK, Hu SL, Hensley SE, Cancro MP, Haynes BF, Weissman D. Pardi N, et al. Among authors: tam yk. J Exp Med. 2018 Jun 4;215(6):1571-1588. doi: 10.1084/jem.20171450. Epub 2018 May 8. J Exp Med. 2018. PMID: 29739835 Free PMC article.
PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake.
Parhiz H, Shuvaev VV, Pardi N, Khoshnejad M, Kiseleva RY, Brenner JS, Uhler T, Tuyishime S, Mui BL, Tam YK, Madden TD, Hope MJ, Weissman D, Muzykantov VR. Parhiz H, et al. Among authors: tam yk. J Control Release. 2018 Dec 10;291:106-115. doi: 10.1016/j.jconrel.2018.10.015. Epub 2018 Oct 15. J Control Release. 2018. PMID: 30336167 Free PMC article.
Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques.
Pardi N, LaBranche CC, Ferrari G, Cain DW, Tombácz I, Parks RJ, Muramatsu H, Mui BL, Tam YK, Karikó K, Polacino P, Barbosa CJ, Madden TD, Hope MJ, Haynes BF, Montefiori DC, Hu SL, Weissman D. Pardi N, et al. Among authors: tam yk. Mol Ther Nucleic Acids. 2019 Apr 15;15:36-47. doi: 10.1016/j.omtn.2019.03.003. Epub 2019 Mar 21. Mol Ther Nucleic Acids. 2019. PMID: 30974332 Free PMC article.
Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood-brain barrier.
Marcos-Contreras OA, Greineder CF, Kiseleva RY, Parhiz H, Walsh LR, Zuluaga-Ramirez V, Myerson JW, Hood ED, Villa CH, Tombacz I, Pardi N, Seliga A, Mui BL, Tam YK, Glassman PM, Shuvaev VV, Nong J, Brenner JS, Khoshnejad M, Madden T, Weissmann D, Persidsky Y, Muzykantov VR. Marcos-Contreras OA, et al. Among authors: tam yk. Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3405-3414. doi: 10.1073/pnas.1912012117. Epub 2020 Jan 31. Proc Natl Acad Sci U S A. 2020. PMID: 32005712 Free PMC article.
226 results