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A Novel P-III Metalloproteinase from Bothrops barnetti Venom Degrades Extracellular Matrix Proteins, Inhibits Platelet Aggregation, and Disrupts Endothelial Cell Adhesion via α5β1 Integrin Receptors to Arginine-Glycine-Aspartic Acid (RGD)-Containing Molecules.
Schluga PHC, Larangote D, de Melo AM, Lobermayer GK, Torrejón D, de Oliveira LS, Alvarenga VG, Vivas-Ruiz DE, Veiga SS, Sanchez EF, Gremski LH. Schluga PHC, et al. Among authors: alvarenga vg. Toxins (Basel). 2024 Nov 9;16(11):486. doi: 10.3390/toxins16110486. Toxins (Basel). 2024. PMID: 39591241 Free PMC article.
Pictolysin-III, a Hemorrhagic Type-III Metalloproteinase Isolated from Bothrops pictus (Serpentes: Viperidae) Venom, Reduces Mitochondrial Respiration and Induces Cytokine Secretion in Epithelial and Stromal Cell Lines.
Vivas-Ruiz DE, Rosas P, Proleón A, Torrejón D, Lazo F, Tenorio-Ricca AB, Guajardo F, Almarza C, Andrades V, Astorga J, Oropesa D, Toledo J, Vera MJ, Martínez J, Araya-Maturana R, Dubois-Camacho K, Hermoso MA, Alvarenga VG, Sanchez EF, Yarlequé A, Oliveira LS, Urra FA. Vivas-Ruiz DE, et al. Among authors: alvarenga vg. Pharmaceutics. 2023 May 18;15(5):1533. doi: 10.3390/pharmaceutics15051533. Pharmaceutics. 2023. PMID: 37242775 Free PMC article.
Fibrinogen-clotting enzyme, pictobin, from Bothrops pictus snake venom. Structural and functional characterization.
Vivas-Ruiz DE, Sandoval GA, Gonzalez-Kozlova E, Zarria-Romero J, Lazo F, Rodríguez E, Magalhães HPB, Chávez-Olortegui C, Oliveira LS, Alvarenga VG, Urra FA, Toledo J, Yarlequé A, Eble JA, Sanchez EF. Vivas-Ruiz DE, et al. Among authors: alvarenga vg. Int J Biol Macromol. 2020 Jun 15;153:779-795. doi: 10.1016/j.ijbiomac.2020.03.055. Epub 2020 Mar 10. Int J Biol Macromol. 2020. PMID: 32169454
Molecular characterization of Lys49 and Asp49 phospholipases A₂from snake venom and their antiviral activities against Dengue virus.
Cecilio AB, Caldas S, Oliveira RA, Santos AS, Richardson M, Naumann GB, Schneider FS, Alvarenga VG, Estevão-Costa MI, Fuly AL, Eble JA, Sanchez EF. Cecilio AB, et al. Among authors: alvarenga vg. Toxins (Basel). 2013 Oct 15;5(10):1780-98. doi: 10.3390/toxins5101780. Toxins (Basel). 2013. PMID: 24131891 Free PMC article.