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Formulation development of dual-compartment topical inserts combining tenofovir alafenamide and elvitegravir for flexible on-demand HIV prevention.
Agrahari V, Peet MM, Chandra N, Ramalingam P, Gupta PK, Jonnalagadda S, Singh ON, McCormick TJ, Doncel GF, Clark MR. Agrahari V, et al. Among authors: doncel gf. J Control Release. 2025 Jan 10;377:842-854. doi: 10.1016/j.jconrel.2024.11.062. Epub 2024 Dec 6. J Control Release. 2025. PMID: 39592025 Free article.
Single dose topical inserts containing tenofovir alafenamide fumarate and elvitegravir provide pre- and post-exposure protection against vaginal SHIV infection in macaques.
Dobard CW, Peet MM, Nishiura K, Holder A, Dinh C, Mitchell J, Khalil G, Pan Y, Singh ON, McCormick TJ, Agrahari V, Gupta P, Jonnalagadda S, Heneine W, Clark MR, García-Lerma JG, Doncel GF. Dobard CW, et al. Among authors: doncel gf. EBioMedicine. 2022 Dec;86:104361. doi: 10.1016/j.ebiom.2022.104361. Epub 2022 Nov 21. EBioMedicine. 2022. PMID: 36423375 Free PMC article.
Pharmacokinetics and efficacy of topical inserts containing tenofovir alafenamide fumarate and elvitegravir administered rectally in macaques.
Makarova N, Singletary T, Peet MM, Mitchell J, Holder A, Dinh C, Agrahari V, Mendoza M, Pan Y, Heneine W, Clark MR, García-Lerma JG, Smith JM, Doncel GF. Makarova N, et al. Among authors: doncel gf. EBioMedicine. 2022 Dec;86:104338. doi: 10.1016/j.ebiom.2022.104338. Epub 2022 Nov 5. EBioMedicine. 2022. PMID: 36343572 Free PMC article.
Extended Postexposure Protection Against Vaginal Simian/Human Immunodeficiency Virus Infection With Tenofovir Alafenamide Fumarate/Elvitegravir Inserts in Macaques.
Makarova N, Singletary T, Peet MM, Mitchell J, Bachman S, Holder A, Dinh C, Lipscomb J, Agrahari V, Mendoza M, Pan Y, Heneine W, Clark MR, García-Lerma JG, Doncel GF, Smith JM. Makarova N, et al. Among authors: doncel gf. J Infect Dis. 2024 Jun 14;229(6):1791-1795. doi: 10.1093/infdis/jiad599. J Infect Dis. 2024. PMID: 38134382 Free PMC article.
A Phase 1 Clinical Trial to Assess the Safety and Pharmacokinetics of a Tenofovir Alafenamide/Elvitegravir Insert Administered Rectally for HIV Prevention.
Riddler SA, Kelly CW, Hoesley CJ, Ho KS, Piper JM, Edick S, Heard F, Doncel GF, Johnson S, Anderson PL, Brand RM, Kunjara Na Ayudhya RP, Bauermeister JA, Hillier SL, Hendrix CW. Riddler SA, et al. Among authors: doncel gf. J Infect Dis. 2024 Sep 23;230(3):696-705. doi: 10.1093/infdis/jiae211. J Infect Dis. 2024. PMID: 38655842 Clinical Trial.
176 results