Huang TT - Search Results

1

Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition.

Nam M, Xia W, Mir AH, Jerrett A, Spinelli JB, Huang TT, Possemato R. Nam M, et al. Among authors: huang tt. Nat Metab. 2024 Dec;6(12):2338-2353. doi: 10.1038/s42255-024-01166-w. Epub 2024 Nov 26. Nat Metab. 2024. PMID: 39592843

2

Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε.

Sviderskiy VO, Blumenberg L, Gorodetsky E, Karakousi TR, Hirsh N, Alvarez SW, Terzi EM, Kaparos E, Whiten GC, Ssebyala S, Tonzi P, Mir H, Neel BG, Huang TT, Adams S, Ruggles KV, Possemato R. Sviderskiy VO, et al. Among authors: huang tt. Mol Cell. 2020 Nov 19;80(4):682-698.e7. doi: 10.1016/j.molcel.2020.10.016. Epub 2020 Nov 4. Mol Cell. 2020. PMID: 33152268 Free PMC article.

3

Dormant origin firing promotes head-on transcription-replication conflicts at transcription termination sites in response to BRCA2 deficiency.

Goehring L, Keegan S, Lahiri S, Xia W, Kong M, Jimenez-Sainz J, Gupta D, Drapkin R, Jensen RB, Smith DJ, Rothenberg E, Fenyö D, Huang TT. Goehring L, et al. Among authors: huang tt. Nat Commun. 2024 Jun 3;15(1):4716. doi: 10.1038/s41467-024-48286-1. Nat Commun. 2024. PMID: 38830843 Free PMC article.

4

USP1-trapping lesions as a source of DNA replication stress and genomic instability.

Coleman KE, Yin Y, Lui SKL, Keegan S, Fenyo D, Smith DJ, Rothenberg E, Huang TT. Coleman KE, et al. Among authors: huang tt. Nat Commun. 2022 Apr 1;13(1):1740. doi: 10.1038/s41467-022-29369-3. Nat Commun. 2022. PMID: 35365626 Free PMC article.

5

Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling.

Lee WTC, Yin Y, Morten MJ, Tonzi P, Gwo PP, Odermatt DC, Modesti M, Cantor SB, Gari K, Huang TT, Rothenberg E. Lee WTC, et al. Among authors: huang tt. Nat Commun. 2021 May 5;12(1):2525. doi: 10.1038/s41467-021-22830-9. Nat Commun. 2021. PMID: 33953191 Free PMC article.

6

Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery.

Tonzi P, Yin Y, Lee CWT, Rothenberg E, Huang TT. Tonzi P, et al. Among authors: huang tt. Elife. 2018 Nov 13;7:e41426. doi: 10.7554/eLife.41426. Elife. 2018. PMID: 30422114 Free PMC article.

7

Monitoring genome-wide replication fork directionality by Okazaki fragment sequencing in mammalian cells.

Kit Leng Lui S, Keegan S, Tonzi P, Kahli M, Chen YH, Chalhoub N, Coleman KE, Fenyo D, Smith DJ, Huang TT. Kit Leng Lui S, et al. Among authors: huang tt. Nat Protoc. 2021 Feb;16(2):1193-1218. doi: 10.1038/s41596-020-00454-5. Epub 2021 Jan 13. Nat Protoc. 2021. PMID: 33442052 Free PMC article.

8

FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.

Sims AE, Spiteri E, Sims RJ 3rd, Arita AG, Lach FP, Landers T, Wurm M, Freund M, Neveling K, Hanenberg H, Auerbach AD, Huang TT. Sims AE, et al. Among authors: huang tt. Nat Struct Mol Biol. 2007 Jun;14(6):564-7. doi: 10.1038/nsmb1252. Epub 2007 Apr 25. Nat Struct Mol Biol. 2007. PMID: 17460694

9

Transcription shapes DNA replication initiation and termination in human cells.

Chen YH, Keegan S, Kahli M, Tonzi P, Fenyö D, Huang TT, Smith DJ. Chen YH, et al. Among authors: huang tt. Nat Struct Mol Biol. 2019 Jan;26(1):67-77. doi: 10.1038/s41594-018-0171-0. Epub 2018 Dec 31. Nat Struct Mol Biol. 2019. PMID: 30598550 Free PMC article.

10

Role of Y-family translesion DNA polymerases in replication stress: Implications for new cancer therapeutic targets.

Tonzi P, Huang TT. Tonzi P, et al. Among authors: huang tt. DNA Repair (Amst). 2019 Jun;78:20-26. doi: 10.1016/j.dnarep.2019.03.016. Epub 2019 Mar 29. DNA Repair (Amst). 2019. PMID: 30954011 Free PMC article. Review.

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