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CYP3A4-Mediated Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor JNJ-54861911 Results in Redox-Neutral Addition of Glutathione via Catalysis by Glutathione S-Transferase α1, Identified as the Major Target Protein in Human Hepatocytes.
Leclercq L, de Vries R, Koppen V, Verboven P, Cuyckens F, Wynant I, Vermeulen WAA, Naisbitt D, Ford M, Meng X, Sakamoto S, Fukushima T, Snoeys J. Leclercq L, et al. Among authors: verboven p. Chem Res Toxicol. 2024 Dec 11. doi: 10.1021/acs.chemrestox.4c00279. Online ahead of print. Chem Res Toxicol. 2024. PMID: 39662968
A Pangenotypic Hepatitis E Virus Replication Inhibitor With High Potency in a Rat Infection Model.
Zhang X, Klöhn M, Ouwerkerk-Mahadevan S, Jagst M, Vereyken L, Verboven P, Goovaerts Q, Todt D, Jonckers THM, Coelmont L, Fletcher H, Das K, Samby K, Neyts J, Steinmann E, Koul A, Kaptein SJF. Zhang X, et al. Among authors: verboven p. Gastroenterology. 2024 Nov 23:S0016-5085(24)05696-8. doi: 10.1053/j.gastro.2024.10.043. Online ahead of print. Gastroenterology. 2024. PMID: 39581510 Free article.
Visualizing the structural and chemical heterogeneity of fruit and vegetables using advanced imaging techniques: fundamentals, instrumental aspects, applications and future perspectives.
Lan W, Hui X, Nicolaï B, Verboven P, Qin J, Renard CMGC, Jaillais B, Tu K, Bureau S, Pan L. Lan W, et al. Among authors: verboven p. Crit Rev Food Sci Nutr. 2024 Jul 30:1-25. doi: 10.1080/10408398.2024.2384650. Online ahead of print. Crit Rev Food Sci Nutr. 2024. PMID: 39081017 Review.
Intestinal organoids as an in vitro platform to characterize disposition, metabolism, and safety profile of small molecules.
Kourula S, Derksen M, Jardi F, Jonkers S, van Heerden M, Verboven P, Theuns V, Van Asten S, Huybrechts T, Kunze A, Frazer-Mendelewska E, Lai KW, Overmeer R, Roos JL, Vries RGJ, Boj SF, Monshouwer M, Pourfarzad F, Snoeys J. Kourula S, et al. Among authors: verboven p. Eur J Pharm Sci. 2023 Sep 1;188:106481. doi: 10.1016/j.ejps.2023.106481. Epub 2023 May 25. Eur J Pharm Sci. 2023. PMID: 37244450 Free article.
107 results