Huang TT - Search Results

1

Poly (ADP-Ribose) Polymerase Inhibitor Olaparib-Resistant BRCA1-Mutant Ovarian Cancer Cells Demonstrate Differential Sensitivity to PARP Inhibitor Rechallenge.

Shih CT, Huang TT, Nair JR, Ibanez KR, Lee JM. Shih CT, et al. Among authors: huang tt. Cells. 2024 Nov 7;13(22):1847. doi: 10.3390/cells13221847. Cells. 2024. PMID: 39594596 Free PMC article.

2

Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer.

Nair J, Huang TT, Murai J, Haynes B, Steeg PS, Pommier Y, Lee JM. Nair J, et al. Among authors: huang tt. Oncogene. 2020 Aug;39(33):5520-5535. doi: 10.1038/s41388-020-1383-4. Epub 2020 Jul 9. Oncogene. 2020. PMID: 32647134 Free PMC article.

3

Targeting the PI3K/mTOR Pathway Augments CHK1 Inhibitor-Induced Replication Stress and Antitumor Activity in High-Grade Serous Ovarian Cancer.

Huang TT, Brill E, Nair JR, Zhang X, Wilson KM, Chen L, Thomas CJ, Lee JM. Huang TT, et al. Cancer Res. 2020 Dec 1;80(23):5380-5392. doi: 10.1158/0008-5472.CAN-20-1439. Epub 2020 Sep 30. Cancer Res. 2020. PMID: 32998994 Free PMC article.

4

Cell cycle checkpoints and beyond: Exploiting the ATR/CHK1/WEE1 pathway for the treatment of PARP inhibitor-resistant cancer.

Gupta N, Huang TT, Horibata S, Lee JM. Gupta N, et al. Among authors: huang tt. Pharmacol Res. 2022 Apr;178:106162. doi: 10.1016/j.phrs.2022.106162. Epub 2022 Mar 5. Pharmacol Res. 2022. PMID: 35259479 Free PMC article. Review.

5

Distinct roles of treatment schemes and BRCA2 on the restoration of homologous recombination DNA repair and PARP inhibitor resistance in ovarian cancer.

Huang TT, Burkett SS, Tandon M, Yamamoto TM, Gupta N, Bitler BG, Lee JM, Nair JR. Huang TT, et al. Oncogene. 2022 Nov;41(46):5020-5031. doi: 10.1038/s41388-022-02491-8. Epub 2022 Oct 12. Oncogene. 2022. PMID: 36224341 Free PMC article.

6

BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor-resistant BRCA-mutant ovarian cancer.

Gupta N, Huang TT, Nair JR, An D, Zurcher G, Lampert EJ, McCoy A, Cimino-Mathews A, Swisher EM, Radke MR, Lockwood CM, Reichel JB, Chiang CY, Wilson KM, Cheng KC, Nousome D, Lee JM. Gupta N, et al. Among authors: huang tt. Sci Transl Med. 2023 Jun 21;15(701):eadd7872. doi: 10.1126/scitranslmed.add7872. Epub 2023 Jun 21. Sci Transl Med. 2023. PMID: 37343085 Free PMC article. Clinical Trial.

7

AKT1 interacts with DHX9 to Mitigate R Loop-Induced Replication Stress in Ovarian Cancer.

Huang TT, Chiang CY, Nair JR, Wilson KM, Cheng K, Lee JM. Huang TT, et al. Cancer Res. 2024 Mar 15;84(6):887-904. doi: 10.1158/0008-5472.CAN-23-1908. Cancer Res. 2024. PMID: 38241710 Free PMC article.

8

The CHK1 inhibitor prexasertib in BRCA wild-type platinum-resistant recurrent high-grade serous ovarian carcinoma: a phase 2 trial.

Giudice E, Huang TT, Nair JR, Zurcher G, McCoy A, Nousome D, Radke MR, Swisher EM, Lipkowitz S, Ibanez K, Donohue D, Malys T, Lee MJ, Redd B, Levy E, Rastogi S, Sato N, Trepel JB, Lee JM. Giudice E, et al. Among authors: huang tt. Nat Commun. 2024 Mar 30;15(1):2805. doi: 10.1038/s41467-024-47215-6. Nat Commun. 2024. PMID: 38555285 Free PMC article. Clinical Trial.

9

Combination Therapy Approach to Overcome the Resistance to PI3K Pathway Inhibitors in Gynecological Cancers.

Ibanez KR, Huang TT, Lee JM. Ibanez KR, et al. Among authors: huang tt. Cells. 2024 Jun 19;13(12):1064. doi: 10.3390/cells13121064. Cells. 2024. PMID: 38920692 Free PMC article. Review.

10

Targeting the PI3K pathway and DNA damage response as a therapeutic strategy in ovarian cancer.

Huang TT, Lampert EJ, Coots C, Lee JM. Huang TT, et al. Cancer Treat Rev. 2020 Jun;86:102021. doi: 10.1016/j.ctrv.2020.102021. Epub 2020 Apr 10. Cancer Treat Rev. 2020. PMID: 32311593 Free PMC article. Review.

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