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Deregulated E2F Activity as a Cancer-Cell Specific Therapeutic Tool.
Nakajima R, Zhao L, Zhou Y, Shirasawa M, Uchida A, Murakawa H, Fikriyanti M, Iwanaga R, Bradford AP, Araki K, Warita T, Ohtani K. Nakajima R, et al. Among authors: iwanaga r. Genes (Basel). 2023 Feb 2;14(2):393. doi: 10.3390/genes14020393. Genes (Basel). 2023. PMID: 36833320 Free PMC article. Review.
The TFDP1 gene coding for DP1, the heterodimeric partner of the transcription factor E2F, is a target of deregulated E2F.
Nakajima R, Deguchi R, Komori H, Zhao L, Zhou Y, Shirasawa M, Angelina A, Goto Y, Tohjo F, Nakahashi K, Nakata K, Iwanaga R, Bradford AP, Araki K, Warita T, Ohtani K. Nakajima R, et al. Among authors: iwanaga r. Biochem Biophys Res Commun. 2023 Jun 30;663:154-162. doi: 10.1016/j.bbrc.2023.04.092. Epub 2023 Apr 25. Biochem Biophys Res Commun. 2023. PMID: 37141667
Activation of the CDK7 Gene, Coding for the Catalytic Subunit of the Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) and General Transcription Factor II H, by the Trans-Activator Protein Tax of Human T-Cell Leukemia Virus Type-1.
Shirasawa M, Nakajima R, Zhou Y, Zhao L, Fikriyanti M, Iwanaga R, Bradford AP, Kurayoshi K, Araki K, Ohtani K. Shirasawa M, et al. Among authors: iwanaga r. Genes (Basel). 2024 Aug 15;15(8):1080. doi: 10.3390/genes15081080. Genes (Basel). 2024. PMID: 39202439 Free PMC article.
Ectopic expression of the CDK inhibitor p21Cip1 enhances deregulated E2F activity and increases cancer cell-specific cytotoxic gene expression mediated by the ARF tumor suppressor promoter.
Kurayoshi K, Shiromoto A, Ozono E, Iwanaga R, Bradford AP, Araki K, Ohtani K. Kurayoshi K, et al. Among authors: iwanaga r. Biochem Biophys Res Commun. 2017 Jan 29;483(1):107-114. doi: 10.1016/j.bbrc.2016.12.185. Epub 2016 Dec 29. Biochem Biophys Res Commun. 2017. PMID: 28042030
122 results