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Human histone demethylase KDM6B can catalyse sequential oxidations.
Hopkinson RJ , Langley GW , Belle R , Walport LJ , Dunne K , Münzel M , Salah E , Kawamura A , Claridge TDW , Schofield CJ . Hopkinson RJ , et al. Among authors: schofield cj. Chem Commun (Camb). 2018 Jul 12;54(57):7975-7978. doi: 10.1039/c8cc04057e. Chem Commun (Camb). 2018. PMID: 29961803 Free PMC article.
Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.
Woon EC, Tumber A, Kawamura A, Hillringhaus L, Ge W, Rose NR, Ma JH, Chan MC, Walport LJ, Che KH, Ng SS, Marsden BD, Oppermann U, McDonough MA, Schofield CJ. Woon EC, et al. Among authors: schofield cj. Angew Chem Int Ed Engl. 2012 Feb 13;51(7):1631-4. doi: 10.1002/anie.201107833. Epub 2012 Jan 12. Angew Chem Int Ed Engl. 2012. PMID: 22241642 No abstract available.
733 results