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Page 1
Single-cell transcriptomic landscape of the neuroimmune compartment in amyotrophic lateral sclerosis brain and spinal cord.
Tuddenham JF, Fujita M, Khairallah A, Harbison C, Flowers XE, Coronas-Samano G, Maniatis S, Daly A, Schneider JA, Teich AF, Vonsattel JPG, Sims PA, Elyaman W, Bradshaw EM, Phatnani H, Shneider N, Bennett DA, De Jager PL, Przedborski S, Menon V, Olah M. Tuddenham JF, et al. bioRxiv [Preprint]. 2024 Nov 14:2024.11.12.623183. doi: 10.1101/2024.11.12.623183. bioRxiv. 2024. PMID: 39605399 Free PMC article. Preprint.
HDAC Inhibitors recapitulate Human Disease-Associated Microglia Signatures in vitro.
Haage V, Tuddenham JF, Bautista A, White CC, Garcia F, Patel R, Comandante-Lou N, Marshe V, Soni RK, Sims PA, Menon V, Sproul AA, De Jager PL. Haage V, et al. Among authors: tuddenham jf. bioRxiv [Preprint]. 2024 Oct 12:2024.10.11.617544. doi: 10.1101/2024.10.11.617544. bioRxiv. 2024. PMID: 39416157 Free PMC article. Preprint.
A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial states.
Tuddenham JF, Taga M, Haage V, Marshe VS, Roostaei T, White C, Lee AJ, Fujita M, Khairallah A, Zhang Y, Green G, Hyman B, Frosch M, Hopp S, Beach TG, Serrano GE, Corboy J, Habib N, Klein HU, Soni RK, Teich AF, Hickman RA, Alcalay RN, Shneider N, Schneider J, Sims PA, Bennett DA, Olah M, Menon V, De Jager PL. Tuddenham JF, et al. Nat Neurosci. 2024 Dec;27(12):2521-2537. doi: 10.1038/s41593-024-01764-7. Epub 2024 Oct 15. Nat Neurosci. 2024. PMID: 39406950
A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease.
Haage V, Tuddenham JF, Comandante-Lou N, Bautista A, Monzel A, Chiu R, Fujita M, Garcia FG, Bhattarai P, Patel R, Buonfiglioli A, Idiarte J, Herman M, Rinderspacher A, Mela A, Zhao W, Argenziano MG, Furnari JL, Banu MA, Landry DW, Bruce JN, Canoll P, Zhang Y, Nuriel T, Kizil C, Sproul AA, de Witte LD, Sims PA, Menon V, Picard M, De Jager PL. Haage V, et al. Among authors: tuddenham jf. bioRxiv [Preprint]. 2024 Feb 6:2024.02.06.579103. doi: 10.1101/2024.02.06.579103. bioRxiv. 2024. PMID: 38370689 Free PMC article. Preprint.
Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic and targetable tissue states.
Al-Dalahmah O, Argenziano MG, Kannan A, Mahajan A, Furnari J, Paryani F, Boyett D, Save A, Humala N, Khan F, Li J, Lu H, Sun Y, Tuddenham JF, Goldberg AR, Dovas A, Banu MA, Sudhakar T, Bush E, Lassman AB, McKhann GM, Gill BJA, Youngerman B, Sisti MB, Bruce JN, Sims PA, Menon V, Canoll P. Al-Dalahmah O, et al. Among authors: tuddenham jf. Nat Commun. 2023 May 4;14(1):2586. doi: 10.1038/s41467-023-38186-1. Nat Commun. 2023. PMID: 37142563 Free PMC article.
Biomarkers of multiple sclerosis: current findings.
Harris VK, Tuddenham JF, Sadiq SA. Harris VK, et al. Among authors: tuddenham jf. Degener Neurol Neuromuscul Dis. 2017 Jan 12;7:19-29. doi: 10.2147/DNND.S98936. eCollection 2017. Degener Neurol Neuromuscul Dis. 2017. PMID: 30050375 Free PMC article. Review.