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Requirement for Fc effector function is overcome by binding potency for broadly reactive anti-alphavirus antibodies.
Callahan V, Sutton MS, Gardner CL, Kenchegowda D, Dunagan MM, Gosavi M, Green C, Chen TY, Prado-Smith J, Long D, Vogel JL, Kristie TM, Clancy CS, Burke CW, Roederer M, Fox JM. Callahan V, et al. Among authors: roederer m. bioRxiv [Preprint]. 2024 Nov 3:2024.11.03.619087. doi: 10.1101/2024.11.03.619087. bioRxiv. 2024. PMID: 39605662 Free PMC article. Preprint.
Antibody-mediated depletion of select T cell subsets in blood and tissue of nonhuman primates.
Sutton MS, Bucsan AN, Lehman CC, Kamath M, Pokkali S, Magnani DM, Seder R, Darrah PA, Roederer M. Sutton MS, et al. Among authors: roederer m. bioRxiv [Preprint]. 2023 Dec 23:2023.12.22.572898. doi: 10.1101/2023.12.22.572898. bioRxiv. 2023. Update in: Front Immunol. 2024 Mar 11;15:1359679. doi: 10.3389/fimmu.2024.1359679 PMID: 38187627 Free PMC article. Updated. Preprint.
Protective intravenous BCG vaccination induces enhanced immune signaling in the airways.
Peters JM, Irvine EB, Rosenberg JM, Wadsworth MH, Hughes TK, Sutton M, Nyquist SK, Bromley JD, Mondal R, Roederer M, Seder RA, Darrah PA, Alter G, Flynn JL, Shalek AK, Fortune SM, Bryson BD. Peters JM, et al. Among authors: roederer m. bioRxiv [Preprint]. 2023 Jul 18:2023.07.16.549208. doi: 10.1101/2023.07.16.549208. bioRxiv. 2023. Update in: Sci Adv. 2025 Jan 3;11(1):eadq8229. doi: 10.1126/sciadv.adq8229 PMID: 37502895 Free PMC article. Updated. Preprint.
CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques.
Simonson AW, Zeppa JJ, Bucsan AN, Chao MC, Pokkali S, Hopkins F, Chase MR, Vickers AJ, Sutton MS, Winchell CG, Myers AJ, Ameel CL, Kelly R, Krouse B, Hood LE, Li J, Lehman CC, Kamath M, Tomko J, Rodgers MA, Donlan R, Chishti H, Jacob Borish H, Klein E, Scanga CA, Fortune S, Lin PL, Maiello P, Roederer M, Darrah PA, Seder RA, Flynn JL. Simonson AW, et al. Among authors: roederer m. bioRxiv [Preprint]. 2024 May 17:2024.05.14.594183. doi: 10.1101/2024.05.14.594183. bioRxiv. 2024. PMID: 38798646 Free PMC article. Preprint.
Durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants.
Pegu A, O'Connell S, Schmidt SD, O'Dell S, Talana CA, Lai L, Albert J, Anderson E, Bennett H, Corbett KS, Flach B, Jackson L, Leav B, Ledgerwood JE, Luke CJ, Makowski M, Roberts PC, Roederer M, Rebolledo PA, Rostad CA, Rouphael NG, Shi W, Wang L, Widge AT, Yang ES; mRNA-1273 Study Group; Beigel JH, Graham BS, Mascola JR, Suthar MS, McDermott A, Doria-Rose NA. Pegu A, et al. Among authors: roederer m. bioRxiv [Preprint]. 2021 May 16:2021.05.13.444010. doi: 10.1101/2021.05.13.444010. bioRxiv. 2021. Update in: Science. 2021 Sep 17;373(6561):1372-1377. doi: 10.1126/science.abj4176 PMID: 34031659 Free PMC article. Updated. Preprint.
Immune Correlates of Protection by mRNA-1273 Immunization against SARS-CoV-2 Infection in Nonhuman Primates.
Corbett KS, Nason MC, Flach B, Gagne M, O' Connell S, Johnston TS, Shah SN, Edara VV, Floyd K, Lai L, McDanal C, Francica JR, Flynn B, Wu K, Choi A, Koch M, Abiona OM, Werner AP, Alvarado GS, Andrew SF, Donaldson MM, Fintzi J, Flebbe DR, Lamb E, Noe AT, Nurmukhambetova ST, Provost SJ, Cook A, Dodson A, Faudree A, Greenhouse J, Kar S, Pessaint L, Porto M, Steingrebe K, Valentin D, Zouantcha S, Bock KW, Minai M, Nagata BM, Moliva JI, van de Wetering R, Boyoglu-Barnum S, Leung K, Shi W, Yang ES, Zhang Y, Todd JM, Wang L, Andersen H, Foulds KE, Edwards DK, Mascola JR, Moore IN, Lewis MG, Carfi A, Montefiori D, Suthar MS, McDermott A, Sullivan NJ, Roederer M, Douek DC, Graham BS, Seder RA. Corbett KS, et al. Among authors: roederer m. bioRxiv [Preprint]. 2021 Apr 23:2021.04.20.440647. doi: 10.1101/2021.04.20.440647. bioRxiv. 2021. Update in: Science. 2021 Sep 17;373(6561):eabj0299. doi: 10.1126/science.abj0299 PMID: 33907752 Free PMC article. Updated. Preprint.
Humoral correlates of protection against Mycobacterium tuberculosis following intravenous Bacille Calmette-Guérin vaccination in rhesus macaques.
Irvine EB, Darrah PA, Wang S, Wang C, McNamara RP, Roederer M, Seder RA, Lauffenburger DA, Flynn JL, Fortune SM, Alter G. Irvine EB, et al. Among authors: roederer m. bioRxiv [Preprint]. 2023 Aug 2:2023.07.31.551245. doi: 10.1101/2023.07.31.551245. bioRxiv. 2023. Update in: iScience. 2024 Oct 15;27(12):111128. doi: 10.1016/j.isci.2024.111128 PMID: 37577655 Free PMC article. Updated. Preprint.
Mucosal Adenoviral-vectored Vaccine Boosting Durably Prevents XBB.1.16 Infection in Nonhuman Primates.
Gagne M, Flynn BJ, Andrew SF, Flebbe DR, Mychalowych A, Lamb E, Davis-Gardner ME, Burnett MR, Serebryannyy LA, Lin BC, Pessaint L, Todd JM, Ziff ZE, Maule E, Carroll R, Naisan M, Jethmalani Y, Case JB, Dmitriev IP, Kashentseva EA, Ying B, Dodson A, Kouneski K, Doria-Rose NA, O'Dell S, Godbole S, Laboune F, Henry AR, Marquez J, Teng IT, Wang L, Zhou Q, Wali B, Ellis M, Zouantchangadou S, Ry AV, Lewis MG, Andersen H, Kwong PD, Curiel DT, Foulds KE, Nason MC, Suthar MS, Roederer M, Diamond MS, Douek DC, Seder RA. Gagne M, et al. Among authors: roederer m. bioRxiv [Preprint]. 2023 Nov 8:2023.11.06.565765. doi: 10.1101/2023.11.06.565765. bioRxiv. 2023. Update in: Nat Immunol. 2024 Oct;25(10):1913-1927. doi: 10.1038/s41590-024-01951-5 PMID: 37986823 Free PMC article. Updated. Preprint.
Protection against SARS-CoV-2 Beta Variant in mRNA-1273 Boosted Nonhuman Primates.
Corbett KS, Gagne M, Wagner DA, Connell SO, Narpala SR, Flebbe DR, Andrew SF, Davis RL, Flynn B, Johnston TS, Stringham C, Lai L, Valentin D, Van Ry A, Flinchbaugh Z, Werner AP, Moliva JI, Sriparna M, O'Dell S, Schmidt SD, Tucker C, Choi A, Koch M, Bock KW, Minai M, Nagata BM, Alvarado GS, Henry AR, Laboune F, Schramm CA, Zhang Y, Wang L, Choe M, Boyoglu-Barnum S, Shi W, Lamb E, Nurmukhambetova ST, Provost SJ, Donaldson MM, Marquez J, Todd JM, Cook A, Dodson A, Pekosz A, Boritz E, Ploquin A, Doria-Rose N, Pessaint L, Andersen H, Foulds KE, Misasi J, Wu K, Carfi A, Nason MC, Mascola J, Moore IN, Edwards DK, Lewis MG, Suthar MS, Roederer M, McDermott A, Douek DC, Sullivan NJ, Graham BS, Seder RA. Corbett KS, et al. Among authors: roederer m. bioRxiv [Preprint]. 2021 Aug 12:2021.08.11.456015. doi: 10.1101/2021.08.11.456015. bioRxiv. 2021. Update in: Science. 2021 Dec 10;374(6573):1343-1353. doi: 10.1126/science.abl8912 PMID: 34426813 Free PMC article. Updated. Preprint.
482 results