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An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo.
Chu H, Shuai H, Qiao J, Yoon C, Zhang G, Hou Y, Xia X, Wang L, Deng X, Wang Y, Li Q, Du L, Liu Y, Zhou M, Wong HT, Liu H, Hu B, Chen Y, Fang Z, Xia Z, Chai Y, Shi J, Wang Y, Zhu T, Zhang H, Yuan S, Zhou J, Chan J, Yuen KY, Xu C, Lei J, Yang S. Chu H, et al. Among authors: hu b. Res Sq [Preprint]. 2024 Nov 21:rs.3.rs-5454588. doi: 10.21203/rs.3.rs-5454588/v1. Res Sq. 2024. PMID: 39606435 Free PMC article. Preprint.
A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants.
Huang C, Shuai H, Qiao J, Hou Y, Zeng R, Xia A, Xie L, Fang Z, Li Y, Yoon C, Huang Q, Hu B, You J, Quan B, Zhao X, Guo N, Zhang S, Ma R, Zhang J, Wang Y, Yang R, Zhang S, Nan J, Xu H, Wang F, Lei J, Chu H, Yang S. Huang C, et al. Among authors: hu b. Signal Transduct Target Ther. 2023 Mar 16;8(1):128. doi: 10.1038/s41392-023-01392-w. Signal Transduct Target Ther. 2023. PMID: 36928316 Free PMC article.
Virological features and pathogenicity of SARS-CoV-2 Omicron BA.2.
Chan JF, Hu B, Chai Y, Shuai H, Liu H, Shi J, Liu Y, Yoon C, Zhang J, Hu JC, Hou Y, Huang X, Yuen TT, Zhu T, Li W, Cai JP, Luo C, Yip CC, Zhang AJ, Zhou J, Yuan S, Zhang BZ, Huang JD, To KK, Yuen KY, Chu H. Chan JF, et al. Among authors: hu jc, hu b. Cell Rep Med. 2022 Sep 20;3(9):100743. doi: 10.1016/j.xcrm.2022.100743. Epub 2022 Aug 29. Cell Rep Med. 2022. PMID: 36084644 Free PMC article.
Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron.
Shuai H, Chan JF, Hu B, Chai Y, Yuen TT, Yin F, Huang X, Yoon C, Hu JC, Liu H, Shi J, Liu Y, Zhu T, Zhang J, Hou Y, Wang Y, Lu L, Cai JP, Zhang AJ, Zhou J, Yuan S, Brindley MA, Zhang BZ, Huang JD, To KK, Yuen KY, Chu H. Shuai H, et al. Among authors: hu jc, hu b. Nature. 2022 Mar;603(7902):693-699. doi: 10.1038/s41586-022-04442-5. Epub 2022 Jan 21. Nature. 2022. PMID: 35062016
Altered host protease determinants for SARS-CoV-2 Omicron.
Chan JF, Huang X, Hu B, Chai Y, Shi H, Zhu T, Yuen TT, Liu Y, Liu H, Shi J, Wen L, Shuai H, Hou Y, Yoon C, Cai JP, Zhang AJ, Zhou J, Yin F, Yuan S, Zhang BZ, Brindley MA, Shi ZL, Yuen KY, Chu H. Chan JF, et al. Among authors: hu b. Sci Adv. 2023 Jan 20;9(3):eadd3867. doi: 10.1126/sciadv.add3867. Epub 2023 Jan 20. Sci Adv. 2023. PMID: 36662861 Free PMC article.
Targeting ACLY efficiently inhibits SARS-CoV-2 replication.
Yuen TT, Chan JF, Yan B, Shum CC, Liu Y, Shuai H, Hou Y, Huang X, Hu B, Chai Y, Yoon C, Zhu T, Liu H, Shi J, Zhang J, Cai JP, Zhang AJ, Zhou J, Yin F, Yuan S, Zhang BZ, Chu H. Yuen TT, et al. Among authors: hu b. Int J Biol Sci. 2022 Jul 11;18(12):4714-4730. doi: 10.7150/ijbs.72709. eCollection 2022. Int J Biol Sci. 2022. PMID: 35874959 Free PMC article.
Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity.
Chu H, Shuai H, Hou Y, Zhang X, Wen L, Huang X, Hu B, Yang D, Wang Y, Yoon C, Wong BH, Li C, Zhao X, Poon VK, Cai JP, Wong KK, Yeung ML, Zhou J, Au-Yeung RK, Yuan S, Jin DY, Kok KH, Perlman S, Chan JF, Yuen KY. Chu H, et al. Among authors: hu b. Sci Adv. 2021 Jun 16;7(25):eabf8577. doi: 10.1126/sciadv.abf8577. Print 2021 Jun. Sci Adv. 2021. PMID: 34134991 Free PMC article.
Coronaviruses exploit a host cysteine-aspartic protease for replication.
Chu H, Hou Y, Yang D, Wen L, Shuai H, Yoon C, Shi J, Chai Y, Yuen TT, Hu B, Li C, Zhao X, Wang Y, Huang X, Lee KS, Luo C, Cai JP, Poon VK, Chan CC, Zhang AJ, Yuan S, Sit KY, Foo DC, Au WK, Wong KK, Zhou J, Kok KH, Jin DY, Chan JF, Yuen KY. Chu H, et al. Among authors: hu b. Nature. 2022 Sep;609(7928):785-792. doi: 10.1038/s41586-022-05148-4. Epub 2022 Aug 3. Nature. 2022. PMID: 35922005
The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA.1, BA.2, and BA.5.
Shuai H, Chan JF, Hu B, Chai Y, Yoon C, Liu H, Liu Y, Shi J, Zhu T, Hu JC, Hu YF, Hou Y, Huang X, Yuen TT, Wang Y, Zhang J, Xia Y, Chen LL, Cai JP, Zhang AJ, Yuan S, Zhou J, Zhang BZ, Huang JD, Yuen KY, To KK, Chu H. Shuai H, et al. Among authors: hu jc, hu b, hu yf. EBioMedicine. 2023 Sep;95:104753. doi: 10.1016/j.ebiom.2023.104753. Epub 2023 Aug 12. EBioMedicine. 2023. PMID: 37579626 Free PMC article.
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