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Structure-Activity Relationship of Potent, Selective, and Orally Bioavailable Molecular Glue Degraders of CK1α.
Nishiguchi G, Caine EA, McGowan K, Shi Z, Aggarwal A, Mayasundari A, Price J, Yang L, Li Y, Fu X, Mascibroda LG, Das S, Daniels DL, Urh M, Klco JM, Riching KM, Rankovic Z. Nishiguchi G, et al. Among authors: caine ea. ACS Med Chem Lett. 2024 Sep 12;15(10):1692-1698. doi: 10.1021/acsmedchemlett.4c00250. eCollection 2024 Oct 10. ACS Med Chem Lett. 2024. PMID: 39411539 Free PMC article.
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines.
Nishiguchi G, Mascibroda LG, Young SM, Caine EA, Abdelhamed S, Kooijman JJ, Miller DJ, Das S, McGowan K, Mayasundari A, Shi Z, Barajas JM, Hiltenbrand R, Aggarwal A, Chang Y, Mishra V, Narina S, Thomas M, Loughran AJ, Kalathur R, Yu K, Zhou S, Wang X, High AA, Peng J, Pruett-Miller SM, Daniels DL, Urh M, Shelat AA, Mullighan CG, Riching KM, Zaman GJR, Fischer M, Klco JM, Rankovic Z. Nishiguchi G, et al. Among authors: caine ea. Nat Commun. 2024 Jan 16;15(1):482. doi: 10.1038/s41467-024-44698-1. Nat Commun. 2024. PMID: 38228616 Free PMC article.
An Immunocompetent Mouse Model of Zika Virus Infection.
Gorman MJ, Caine EA, Zaitsev K, Begley MC, Weger-Lucarelli J, Uccellini MB, Tripathi S, Morrison J, Yount BL, Dinnon KH 3rd, Rückert C, Young MC, Zhu Z, Robertson SJ, McNally KL, Ye J, Cao B, Mysorekar IU, Ebel GD, Baric RS, Best SM, Artyomov MN, Garcia-Sastre A, Diamond MS. Gorman MJ, et al. Among authors: caine ea. Cell Host Microbe. 2018 May 9;23(5):672-685.e6. doi: 10.1016/j.chom.2018.04.003. Cell Host Microbe. 2018. PMID: 29746837 Free PMC article.
23 results