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Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency.
Lang PA, Shaabani N, Borkens S, Honke N, Scheu S, Booth S, Brenner D, Meryk A, Barthuber C, Recher M, Mak TW, Ohashi PS, Häussinger D, Griffiths GM, Thrasher AJ, Bouma G, Lang KS. Lang PA, et al. Among authors: griffiths gm. J Allergy Clin Immunol. 2013 Mar;131(3):815-24. doi: 10.1016/j.jaci.2012.08.050. Epub 2012 Nov 6. J Allergy Clin Immunol. 2013. PMID: 23141740 Free PMC article.
Dominant negative variants in ITPR3 impair T cell Ca2+ dynamics causing combined immunodeficiency.
Blanco E, Camps C, Bahal S, Kerai MD, Ferla MP, Rochussen AM, Handel AE, Golwala ZM, Spiridou Goncalves H, Kricke S, Klein F, Zhang F, Zinghirino F, Evans G, Keane TM, Lizot S, Kusters MAA, Iro MA, Patel SV, Morris EC, Burns SO, Radcliffe R, Vasudevan P, Price A, Gillham O, Valdebenito GE, Stewart GS, Worth A, Adams SP, Duchen M, André I, Adams DJ, Santili G, Gilmour KC, Holländer GA, Davies EG, Taylor JC, Griffiths GM, Thrasher AJ, Dhalla F, Kreins AY. Blanco E, et al. Among authors: griffiths gm. J Exp Med. 2025 Jan 6;222(1):e20220979. doi: 10.1084/jem.20220979. Epub 2024 Nov 19. J Exp Med. 2025. PMID: 39560673 Free PMC article.
Clinical and cost-effectiveness of spironolactone in treating persistent facial acne in women: SAFA double-blinded RCT.
Santer M, Lawrence M, Pyne S, Renz S, Stuart BL, Sach T, Ridd M, Thomas KS, Nuttall J, Permyakova N, Eminton Z, Francis N, Little P, Muller I, Soulsby I, Thomas K, Griffiths G, Layton AM. Santer M, et al. Among authors: griffiths g. Health Technol Assess. 2024 Sep;28(56):1-86. doi: 10.3310/MYJT6804. Health Technol Assess. 2024. PMID: 39268864 Free PMC article. Clinical Trial.
A gut microbiota rheostat forecasts responsiveness to PD-L1 and VEGF blockade in mesothelioma.
Zhang M, Bzura A, Baitei EY, Zhou Z, Spicer JB, Poile C, Rogel J, Branson A, King A, Barber S, Kamata T, Dzialo J, Harber J, Greystoke A, Nusrat N, Faulkner D, Sun Q, Nolan L, Hahne JC, Scotland M, Walter H, Darlison L, Morgan B, Bajaj A, Brookes C, Hollox EJ, Lubawska D, Jama M, Griffiths G, Nakas A, Kutywayo K, Luo JL, Klampatsa A, Cooper A, Halder K, Wells-Jordan P, Zhou H, Dudbridge F, Thomas A, Richards CJ, Pritchard C, Yang H, Barer M, Fennell DA. Zhang M, et al. Among authors: griffiths g. Nat Commun. 2024 Aug 21;15(1):7187. doi: 10.1038/s41467-024-49842-5. Nat Commun. 2024. PMID: 39168966 Free PMC article. Clinical Trial.
Internet and Telephone Support for Discontinuing Long-Term Antidepressants: The REDUCE Cluster Randomized Trial.
Kendrick T, Stuart B, Bowers H, Haji Sadeghi M, Page H, Dowrick C, Moore M, Gabbay M, Leydon GM, Yao GL, Little P, Griffiths G, Lewis G, May C, Moncrieff J, Johnson CF, Macleod U, Gilbody S, Dewar-Haggart R, Williams S, O'Brien W, Tiwari R, Woods C, Patel T, Khan N, van Ginneken N, Din A, Reidy C, Lucier R, Palmer B, Becque T, van Leeuwen E, Zhu S, Geraghty AWA. Kendrick T, et al. Among authors: griffiths g. JAMA Netw Open. 2024 Jun 3;7(6):e2418383. doi: 10.1001/jamanetworkopen.2024.18383. JAMA Netw Open. 2024. PMID: 38913372 Free PMC article. Clinical Trial.
Dose escalation of tolinapant (ASTX660) in combination with standard radical chemoradiotherapy in cervical cancer : a study protocol for a phase 1b TiTE-CRM clinical trial (CRAIN) in UK secondary care centres.
Hoskin P, Lee M, Dunkley D, Danh M, Wickens R, Saunders G, Northey J, Crabb S, McFarlane V, Sadozye A, Cooper R, Mathew T, Haslett K, Reeves K, Reed R, Bigos K, Williams KJ, Rowling E, Choudhury A, Dancer S, Smith D, Griffiths G. Hoskin P, et al. Among authors: griffiths g. BMC Cancer. 2024 Jun 7;24(1):702. doi: 10.1186/s12885-024-12310-w. BMC Cancer. 2024. PMID: 38849715 Free PMC article.
Supporting self-management of low back pain with an internet intervention with and without telephone support in primary care (SupportBack 2): a randomised controlled trial of clinical and cost-effectiveness.
Geraghty AWA, Becque T, Roberts LC, Hill JC, Foster NE, Yardley L, Stuart B, Turner DA, Hay E, Griffiths G, Webley F, Durcan L, Morgan A, Hughes S, Bathers S, Butler-Walley S, Wathall S, Mansell G, White M, Davies F, Little P. Geraghty AWA, et al. Among authors: griffiths g. Lancet Rheumatol. 2024 Jul;6(7):e424-e437. doi: 10.1016/S2665-9913(24)00086-9. Epub 2024 May 30. Lancet Rheumatol. 2024. PMID: 38824934 Free article. Clinical Trial.
Lipid switches in the immunological synapse.
Griffiths G, Brügger B, Freund C. Griffiths G, et al. J Biol Chem. 2024 Jul;300(7):107428. doi: 10.1016/j.jbc.2024.107428. Epub 2024 May 30. J Biol Chem. 2024. PMID: 38823638 Free PMC article. Review.
1,081 results