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Characterizing the pharmacological interaction of the antimalarial combination artefenomel-piperaquine in healthy volunteers with induced blood-stage Plasmodium falciparum to predict efficacy in patients with malaria.
Abd-Rahman AN, Kaschek D, Kümmel A, Webster R, Potter AJ, Odedra A, Woolley SD, Llewellyn S, Webb L, Marquart L, Chalon S, Gaaloul ME, McCarthy JS, Möhrle JJ, Barber BE. Abd-Rahman AN, et al. Among authors: gaaloul me. BMC Med. 2024 Nov 28;22(1):563. doi: 10.1186/s12916-024-03787-0. BMC Med. 2024. PMID: 39609822 Free PMC article. Clinical Trial.
Pharmacokinetics of Ganaplacide and Lumefantrine in Adults, Adolescents, and Children with Plasmodium falciparum Malaria Treated with Ganaplacide Plus Lumefantrine Solid Dispersion Formulation: Analysis of Data from a Multinational Phase 2 Study.
Sangana R, Ogutu B, Yeka A, Kusemererwa S, Tinto H, Toure AO, Kibuuka A, Lingani M, Lourenço C, Mombo-Ngoma G, Nduba V, Landry N'Guessan T, Nassa GJW, Nyantaro M, Tina LO, Anvikar A, Sinha A, Kaguthi G, Fofana B, Grobusch MP, Gaaloul ME, Marrast AC, Pathan R, Chikoto H, Csermak K, Risterucci C, Su G, Winnips C, Zhang J, Zack J. Sangana R, et al. Among authors: gaaloul me. J Clin Pharmacol. 2024 Sep 29. doi: 10.1002/jcph.6138. Online ahead of print. J Clin Pharmacol. 2024. PMID: 39344281
A randomized, open-label two-period crossover pilot study to evaluate the relative bioavailability in the fed state of atovaquone-proguanil (Atoguanil™) versus atovaquone-proguanil hydrochloride (Malarone®) in healthy adult participants.
Kuemmerle A, Gossen D, Marx MW, Lorch U, Szramowska M, Kumar A, Singh D, Singh S, Ramachandruni H, Thankachen B, Kore S, Gaaloul ME, Borghini-Fuhrer I, Chalon S. Kuemmerle A, et al. Among authors: gaaloul me. Naunyn Schmiedebergs Arch Pharmacol. 2024 Dec;397(12):9823-9832. doi: 10.1007/s00210-024-03245-x. Epub 2024 Jun 25. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 38918235 Free PMC article. Clinical Trial.
Clinical and population-based study design considerations to accelerate the investigation of new antiretrovirals during pregnancy.
Brummel SS, Stringer J, Mills E, Tierney C, Caniglia EC, Colbers A, Chi BH, Best BM, Gaaloul ME, Hillier S, Jourdain G, Khoo SH, Mofenson LM, Myer L, Nachman S, Stranix-Chibanda L, Clayden P, Sachikonye M, Lockman S. Brummel SS, et al. Among authors: gaaloul me. J Int AIDS Soc. 2022 Jul;25 Suppl 2(Suppl 2):e25917. doi: 10.1002/jia2.25917. J Int AIDS Soc. 2022. PMID: 35851758 Free PMC article.