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Characterizing the pharmacological interaction of the antimalarial combination artefenomel-piperaquine in healthy volunteers with induced blood-stage Plasmodium falciparum to predict efficacy in patients with malaria.
Abd-Rahman AN, Kaschek D, Kümmel A, Webster R, Potter AJ, Odedra A, Woolley SD, Llewellyn S, Webb L, Marquart L, Chalon S, Gaaloul ME, McCarthy JS, Möhrle JJ, Barber BE. Abd-Rahman AN, et al. Among authors: kaschek d. BMC Med. 2024 Nov 28;22(1):563. doi: 10.1186/s12916-024-03787-0. BMC Med. 2024. PMID: 39609822 Free PMC article. Clinical Trial.
BlotIt-Optimal alignment of Western blot and qPCR experiments.
Kemmer S, Bang S, Rosenblatt M, Timmer J, Kaschek D. Kemmer S, et al. Among authors: kaschek d. PLoS One. 2022 Aug 10;17(8):e0264295. doi: 10.1371/journal.pone.0264295. eCollection 2022. PLoS One. 2022. PMID: 35947551 Free PMC article.
Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure.
Hiemstra S, Fehling-Kaschek M, Kuijper IA, Bischoff LJM, Wijaya LS, Rosenblatt M, Esselink J, van Egmond A, Mos J, Beltman JB, Timmer J, van de Water B, Kaschek D. Hiemstra S, et al. Among authors: kaschek d. Sci Rep. 2022 May 5;12(1):7336. doi: 10.1038/s41598-022-10857-x. Sci Rep. 2022. PMID: 35513409 Free PMC article.
Efficient simulation of clinical target response surfaces.
Lill D, Kümmel A, Mitov V, Kaschek D, Gobeau N, Schmidt H, Timmer J. Lill D, et al. Among authors: kaschek d. CPT Pharmacometrics Syst Pharmacol. 2022 Apr;11(4):512-523. doi: 10.1002/psp4.12779. Epub 2022 Mar 11. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 35199969 Free PMC article.
Quantitative Systems Pharmacology: An Exemplar Model-Building Workflow With Applications in Cardiovascular, Metabolic, and Oncology Drug Development.
Helmlinger G, Sokolov V, Peskov K, Hallow KM, Kosinsky Y, Voronova V, Chu L, Yakovleva T, Azarov I, Kaschek D, Dolgun A, Schmidt H, Boulton DW, Penland RC. Helmlinger G, et al. Among authors: kaschek d. CPT Pharmacometrics Syst Pharmacol. 2019 Jun;8(6):380-395. doi: 10.1002/psp4.12426. Epub 2019 Jun 11. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31087533 Free PMC article. Review.
Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.
Oppelt A, Kaschek D, Huppelschoten S, Sison-Young R, Zhang F, Buck-Wiese M, Herrmann F, Malkusch S, Krüger CL, Meub M, Merkt B, Zimmermann L, Schofield A, Jones RP, Malik H, Schilling M, Heilemann M, van de Water B, Goldring CE, Park BK, Timmer J, Klingmüller U. Oppelt A, et al. Among authors: kaschek d. NPJ Syst Biol Appl. 2018 Jun 11;4:23. doi: 10.1038/s41540-018-0058-z. eCollection 2018. NPJ Syst Biol Appl. 2018. PMID: 29900006 Free PMC article.
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