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Adolescent social isolation decreases colonic goblet cells and impairs spatial cognition through the reduction of cystine.
Tanabe M, Kunisawa K, Saito I, Kosuge A, Tezuka H, Kawai T, Kon Y, Yoshidomi K, Kagami A, Hasegawa M, Kubota H, Ojika H, Fujii T, Tochio T, Hirooka Y, Saito K, Nabeshima T, Mouri A. Tanabe M, et al. Among authors: nabeshima t. Mol Psychiatry. 2024 Nov 29. doi: 10.1038/s41380-024-02826-9. Online ahead of print. Mol Psychiatry. 2024. PMID: 39613916
Ido2 Deficiency Exacerbates Motor Impairment and Reduces Aryl Hydrocarbon Receptor Activity through Decreased Kynurenine in a Chronic Demyelinating Mouse Model.
Kunisawa K, Hara M, Yoshidomi K, Kon Y, Yamamoto Y, Fujigaki S, Wulaer B, Kosuge A, Tanabe M, Saitoh S, Takahashi K, Saito K, Nabeshima T, Mouri A. Kunisawa K, et al. Among authors: nabeshima t. Mol Neurobiol. 2025 Jan;62(1):109-122. doi: 10.1007/s12035-024-04263-9. Epub 2024 Jun 3. Mol Neurobiol. 2025. PMID: 38829509
Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine-3-monooxygenase with microglial decline.
Hasegawa M, Kunisawa K, Wulaer B, Kubota H, Kurahashi H, Sakata T, Ando H, Fujigaki S, Fujigaki H, Yamamoto Y, Nagai T, Saito K, Nabeshima T, Mouri A. Hasegawa M, et al. Among authors: nabeshima t. Br J Pharmacol. 2024 Dec 10. doi: 10.1111/bph.17407. Online ahead of print. Br J Pharmacol. 2024. PMID: 39658392
Extracellular and intraneuronal HMW-AbetaOs represent a molecular basis of memory loss in Alzheimer's disease model mouse.
Takamura A, Okamoto Y, Kawarabayashi T, Yokoseki T, Shibata M, Mouri A, Nabeshima T, Sun H, Abe K, Urisu T, Yamamoto N, Shoji M, Yanagisawa K, Michikawa M, Matsubara E. Takamura A, et al. Among authors: nabeshima t. Mol Neurodegener. 2011 Mar 6;6(1):20. doi: 10.1186/1750-1326-6-20. Mol Neurodegener. 2011. PMID: 21375782 Free PMC article.
Maternal immune activation induces neurodevelopmental impairments of adult offspring through alterations in tryptophane-kynurenine pathway in the placenta.
Hasegawa M, Niijima M, Kunisawa K, Teshigawara T, Kubota H, Fujigaki S, Fujigaki H, Yamamoto Y, Kim HC, Saito K, Nabeshima T, Mouri A. Hasegawa M, et al. Among authors: nabeshima t. Biochem Biophys Res Commun. 2024 Dec 10;737:150922. doi: 10.1016/j.bbrc.2024.150922. Epub 2024 Oct 28. Biochem Biophys Res Commun. 2024. PMID: 39486137
1,087 results