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Page 1
ER stress as a sentinel mechanism for ER Ca2+ homeostasis.
Makio T, Chen J, Simmen T. Makio T, et al. Among authors: simmen t. Cell Calcium. 2024 Dec;124:102961. doi: 10.1016/j.ceca.2024.102961. Epub 2024 Oct 18. Cell Calcium. 2024. PMID: 39471738 Free article. Review.
SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA.
Germani S, Van Ho AT, Cherubini A, Varone E, Chernorudskiy A, Renna GM, Fumagalli S, Gobbi M, Lucchetti J, Bolis M, Guarrera L, Craparotta I, Rastelli G, Piccoli G, de Napoli C, Nogara L, Poggio E, Brini M, Cattaneo A, Bachi A, Simmen T, Calì T, Quijano-Roy S, Boncompagni S, Blaauw B, Ferreiro A, Zito E. Germani S, et al. Among authors: simmen t. Cell Rep Med. 2024 Mar 19;5(3):101439. doi: 10.1016/j.xcrm.2024.101439. Epub 2024 Feb 22. Cell Rep Med. 2024. PMID: 38402623 Free PMC article.
Ironing out the mitochondria.
Chen J, Makio T, Simmen T. Chen J, et al. Among authors: simmen t. Nat Chem Biol. 2024 Jun;20(6):658-659. doi: 10.1038/s41589-023-01509-w. Nat Chem Biol. 2024. PMID: 38212577 No abstract available.
Genome-wide kinase-MAM interactome screening reveals the role of CK2A1 in MAM Ca2+ dynamics linked to DEE66.
Thi My Nhung T, Phuoc Long N, Diem Nghi T, Suh Y, Hoang Anh N, Jung CW, Minh Triet H, Jung M, Woo Y, Yoo J, Noh S, Kim SJ, Lee SB, Park S, Thomas G, Simmen T, Mun J, Rhee HW, Kwon SW, Park SK. Thi My Nhung T, et al. Among authors: simmen t. Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2303402120. doi: 10.1073/pnas.2303402120. Epub 2023 Jul 31. Proc Natl Acad Sci U S A. 2023. PMID: 37523531 Free PMC article.
The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to metabolically adapt mitochondria.
Bassot A, Chen J, Takahashi-Yamashiro K, Yap MC, Gibhardt CS, Le GNT, Hario S, Nasu Y, Moore J, Gutiérrez T, Mina L, Mast H, Moses A, Bhat R, Ballanyi K, Lemieux H, Sitia R, Zito E, Bogeski I, Campbell RE, Simmen T. Bassot A, et al. Among authors: simmen t. Cell Rep. 2023 Jan 31;42(1):111899. doi: 10.1016/j.celrep.2022.111899. Epub 2022 Dec 30. Cell Rep. 2023. PMID: 36586409 Free article.
Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance.
Zia S, Hammond BP, Zirngibl M, Sizov A, Baaklini CS, Panda SP, Ho MFS, Lee KV, Mainali A, Burr MK, Williams S, Caprariello AV, Power C, Simmen T, Kerr BJ, Plemel JR. Zia S, et al. Among authors: simmen t. Mol Neurodegener. 2022 Dec 13;17(1):82. doi: 10.1186/s13024-022-00584-2. Mol Neurodegener. 2022. PMID: 36514132 Free PMC article.
72 results