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Page 1
Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis.
Tucci FA, Pennisi R, Rigiracciolo DC, Filippone MG, Bonfanti R, Romeo F, Freddi S, Guerrera E, Soriani C, Rodighiero S, Gunby RH, Jodice G, Sanguedolce F, Renne G, Fusco N, Di Fiore PP, Pruneri G, Bertalot G, Musi G, Vago G, Tosoni D, Pece S. Tucci FA, et al. Among authors: freddi s. Nat Commun. 2024 Dec 3;15(1):10378. doi: 10.1038/s41467-024-54246-6. Nat Commun. 2024. PMID: 39627202 Free PMC article.
CDK12 promotes tumorigenesis but induces vulnerability to therapies inhibiting folate one-carbon metabolism in breast cancer.
Filippone MG, Gaglio D, Bonfanti R, Tucci FA, Ceccacci E, Pennisi R, Bonanomi M, Jodice G, Tillhon M, Montani F, Bertalot G, Freddi S, Vecchi M, Taglialatela A, Romanenghi M, Romeo F, Bianco N, Munzone E, Sanguedolce F, Vago G, Viale G, Di Fiore PP, Minucci S, Alberghina L, Colleoni M, Veronesi P, Tosoni D, Pece S. Filippone MG, et al. Among authors: freddi s. Nat Commun. 2022 May 12;13(1):2642. doi: 10.1038/s41467-022-30375-8. Nat Commun. 2022. PMID: 35550508 Free PMC article. Clinical Trial.
p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response.
Salemme V, Vedelago M, Sarcinella A, Moietta F, Piccolantonio A, Moiso E, Centonze G, Manco M, Guala A, Lamolinara A, Angelini C, Morellato A, Natalini D, Calogero R, Incarnato D, Oliviero S, Conti L, Iezzi M, Tosoni D, Bertalot G, Freddi S, Tucci FA, De Sanctis F, Frusteri C, Ugel S, Bronte V, Cavallo F, Provero P, Gai M, Taverna D, Turco E, Pece S, Defilippi P. Salemme V, et al. Among authors: freddi s. Nat Commun. 2023 May 11;14(1):2350. doi: 10.1038/s41467-023-37824-y. Nat Commun. 2023. PMID: 37169737 Free PMC article.
A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior.
Schiano Lomoriello I, Giangreco G, Iavarone C, Tordonato C, Caldieri G, Serio G, Confalonieri S, Freddi S, Bianchi F, Pirroni S, Bertalot G, Viale G, Disalvatore D, Tosoni D, Malabarba MG, Disanza A, Scita G, Pece S, Pilcher BK, Vecchi M, Sigismund S, Di Fiore PP. Schiano Lomoriello I, et al. Among authors: freddi s. Nat Commun. 2020 Jun 15;11(1):3020. doi: 10.1038/s41467-020-16836-y. Nat Commun. 2020. PMID: 32541686 Free PMC article.
TBC1 domain-containing proteins are frequently involved in triple-negative breast cancers in connection with the induction of a glycolytic phenotype.
Lupi M, Avanzato D, Confalonieri S, Martino F, Pennisi R, Pupo E, Audrito V, Freddi S, Bertalot G, Montani F, Matoskova B, Sigismund S, Di Fiore PP, Lanzetti L. Lupi M, et al. Among authors: freddi s. Cell Death Dis. 2024 Sep 4;15(9):647. doi: 10.1038/s41419-024-07037-2. Cell Death Dis. 2024. PMID: 39231952 Free PMC article.
A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism.
Mesa D, Barbieri E, Raimondi A, Freddi S, Miloro G, Jendrisek G, Caldieri G, Quarto M, Schiano Lomoriello I, Malabarba MG, Bresci A, Manetti F, Vernuccio F, Abdo H, Scita G, Lanzetti L, Polli D, Tacchetti C, Pinton P, Bonora M, Di Fiore PP, Sigismund S. Mesa D, et al. Among authors: freddi s. Nat Commun. 2024 Jun 15;15(1):5119. doi: 10.1038/s41467-024-49543-z. Nat Commun. 2024. PMID: 38879572 Free PMC article.
Comparison of StemPrintER with Oncotype DX Recurrence Score for predicting risk of breast cancer distant recurrence after endocrine therapy.
Pece S, Sestak I, Montani F, Tillhon M, Maisonneuve P, Freddi S, Chu K, Colleoni M, Veronesi P, Disalvatore D, Viale G, Buus R, Cuzick J, Dowsett M, Di Fiore PP. Pece S, et al. Among authors: freddi s. Eur J Cancer. 2022 Mar;164:52-61. doi: 10.1016/j.ejca.2022.01.003. Epub 2022 Feb 15. Eur J Cancer. 2022. PMID: 35172273 Free article. Clinical Trial.
L1CAM promotes ovarian cancer stemness and tumor initiation via FGFR1/SRC/STAT3 signaling.
Giordano M, Decio A, Battistini C, Baronio M, Bianchi F, Villa A, Bertalot G, Freddi S, Lupia M, Jodice MG, Ubezio P, Colombo N, Giavazzi R, Cavallaro U. Giordano M, et al. Among authors: freddi s. J Exp Clin Cancer Res. 2021 Oct 13;40(1):319. doi: 10.1186/s13046-021-02117-z. J Exp Clin Cancer Res. 2021. PMID: 34645505 Free PMC article.
65 results