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19 results

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Page 1
Discovery of CHF-6523, an Inhaled Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease.
Bruno P, Pala D, Micoli A, Corsi M, Accetta A, Carzaniga L, Ronchi P, Fiorelli C, Formica M, Pizzirani D, Mazzucato R, Guariento S, Bertolini S, Martucci C, Allen AD, Mileo V, Capacchi S, Gallo PM, Fioni A, Xanxo Fernandez S, Villetti G, Puccini P, Civelli M, Guala M, Retini M, Martinelli P, Visentini F, Pavoni V, Daldosso M, Fontana S, Biagetti M, Capelli AM. Bruno P, et al. Among authors: visentini f. J Med Chem. 2024 Dec 5. doi: 10.1021/acs.jmedchem.4c02062. Online ahead of print. J Med Chem. 2024. PMID: 39635891
Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one (IC87114) and Its Conformationally Restricted Analogs.
Lodola A, Bertolini S, Biagetti M, Capacchi S, Facchinetti F, Gallo PM, Pappani A, Mor M, Pala D, Rivara S, Visentini F, Corsi M, Capelli AM. Lodola A, et al. Among authors: visentini f. J Med Chem. 2017 May 25;60(10):4304-4315. doi: 10.1021/acs.jmedchem.7b00247. Epub 2017 May 15. J Med Chem. 2017. PMID: 28489362
6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor.
Micheli F, Cavanni P, Andreotti D, Arban R, Benedetti R, Bertani B, Bettati M, Bettelini L, Bonanomi G, Braggio S, Carletti R, Checchia A, Corsi M, Fazzolari E, Fontana S, Marchioro C, Merlo-Pich E, Negri M, Oliosi B, Ratti E, Read KD, Roscic M, Sartori I, Spada S, Tedesco G, Tarsi L, Terreni S, Visentini F, Zocchi A, Zonzini L, Di Fabio R. Micheli F, et al. Among authors: visentini f. J Med Chem. 2010 Jul 8;53(13):4989-5001. doi: 10.1021/jm100481d. J Med Chem. 2010. PMID: 20527970
1-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors.
Micheli F, Cavanni P, Arban R, Benedetti R, Bertani B, Bettati M, Bettelini L, Bonanomi G, Braggio S, Checchia A, Davalli S, Di Fabio R, Fazzolari E, Fontana S, Marchioro C, Minick D, Negri M, Oliosi B, Read KD, Sartori I, Tedesco G, Tarsi L, Terreni S, Visentini F, Zocchi A, Zonzini L. Micheli F, et al. Among authors: visentini f. J Med Chem. 2010 Mar 25;53(6):2534-51. doi: 10.1021/jm901818u. J Med Chem. 2010. PMID: 20170186
In vitro and in vivo characterization of the novel GABAB receptor positive allosteric modulator, 2-{1-[2-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-2-piperidinyl}ethanol (CMPPE).
Perdona' E, Costantini VJ, Tessari M, Martinelli P, Carignani C, Valerio E, Mok MH, Zonzini L, Visentini F, Gianotti M, Gordon L, Rocheville M, Corsi M, Capelli AM. Perdona' E, et al. Among authors: visentini f. Neuropharmacology. 2011 Oct-Nov;61(5-6):957-66. doi: 10.1016/j.neuropharm.2011.06.024. Epub 2011 Jul 5. Neuropharmacology. 2011. PMID: 21756923
1,2,4-Triazolyl 5-Azaspiro[2.4]heptanes: Lead Identification and Early Lead Optimization of a New Series of Potent and Selective Dopamine D3 Receptor Antagonists.
Micheli F, Bacchi A, Braggio S, Castelletti L, Cavallini P, Cavanni P, Cremonesi S, Dal Cin M, Feriani A, Gehanne S, Kajbaf M, Marchió L, Nola S, Oliosi B, Pellacani A, Perdonà E, Sava A, Semeraro T, Tarsi L, Tomelleri S, Wong A, Visentini F, Zonzini L, Heidbreder C. Micheli F, et al. Among authors: visentini f. J Med Chem. 2016 Sep 22;59(18):8549-76. doi: 10.1021/acs.jmedchem.6b00972. Epub 2016 Sep 9. J Med Chem. 2016. PMID: 27564135
1,2,4-Triazolyl octahydropyrrolo[2,3-b]pyrroles: A new series of potent and selective dopamine D3 receptor antagonists.
Micheli F, Bernardelli A, Bianchi F, Braggio S, Castelletti L, Cavallini P, Cavanni P, Cremonesi S, Dal Cin M, Feriani A, Oliosi B, Semeraro T, Tarsi L, Tomelleri S, Wong A, Visentini F, Zonzini L, Heidbreder C. Micheli F, et al. Among authors: visentini f. Bioorg Med Chem. 2016 Apr 15;24(8):1619-36. doi: 10.1016/j.bmc.2016.02.031. Epub 2016 Feb 27. Bioorg Med Chem. 2016. PMID: 26951894
Azabicyclo[3.1.0]hexane-1-carbohydrazides as potent and selective GHSR1a ligands presenting a specific in vivo behavior.
Sabbatini FM, Melotto S, Bernasconi G, Bromidge SM, D'Adamo L, Rinaldi M, Savoia C, Mundi C, Di Francesco C, Zonzini L, Costantini VJ, Perini B, Valerio E, Pozzan A, Perdonà E, Visentini F, Corsi M, Di Fabio R. Sabbatini FM, et al. Among authors: visentini f. ChemMedChem. 2011 Nov 4;6(11):1981-5. doi: 10.1002/cmdc.201100285. Epub 2011 Aug 10. ChemMedChem. 2011. PMID: 21834097 No abstract available.
19 results