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Page 1
In vivo affinity maturation of the CD4 domains of an HIV-1-entry inhibitor.
Pan A, Bailey CC, Ou T, Xu J, Aristotelous T, Liu X, Hu B, Crynen G, Skamangas N, Bronkema N, Tran MH, Mou H, Zhang X, Alpert MD, Yin Y, Farzan M, He W. Pan A, et al. Among authors: aristotelous t. Nat Biomed Eng. 2024 Dec;8(12):1715-1729. doi: 10.1038/s41551-024-01289-1. Epub 2024 Dec 5. Nat Biomed Eng. 2024. PMID: 39638875
O-GlcNAcase Fragment Discovery with Fluorescence Polarimetry.
Borodkin VS, Rafie K, Selvan N, Aristotelous T, Navratilova I, Ferenbach AT, van Aalten DMF. Borodkin VS, et al. Among authors: aristotelous t. ACS Chem Biol. 2018 May 18;13(5):1353-1360. doi: 10.1021/acschembio.8b00183. Epub 2018 May 2. ACS Chem Biol. 2018. PMID: 29641181 Free PMC article.
A mutant O-GlcNAcase enriches Drosophila developmental regulators.
Selvan N, Williamson R, Mariappa D, Campbell DG, Gourlay R, Ferenbach AT, Aristotelous T, Hopkins-Navratilova I, Trost M, van Aalten DMF. Selvan N, et al. Among authors: aristotelous t. Nat Chem Biol. 2017 Aug;13(8):882-887. doi: 10.1038/nchembio.2404. Epub 2017 Jun 12. Nat Chem Biol. 2017. PMID: 28604694 Free PMC article.
Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.
Navratilova I, Aristotelous T, Picaud S, Chaikuad A, Knapp S, Filappakopoulos P, Hopkins AL. Navratilova I, et al. Among authors: aristotelous t. ACS Med Chem Lett. 2016 Sep 20;7(12):1213-1218. doi: 10.1021/acsmedchemlett.6b00154. eCollection 2016 Dec 8. ACS Med Chem Lett. 2016. PMID: 27994766 Free PMC article.
Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor.
Aristotelous T, Ahn S, Shukla AK, Gawron S, Sassano MF, Kahsai AW, Wingler LM, Zhu X, Tripathi-Shukla P, Huang XP, Riley J, Besnard J, Read KD, Roth BL, Gilbert IH, Hopkins AL, Lefkowitz RJ, Navratilova I. Aristotelous T, et al. ACS Med Chem Lett. 2013 Oct 10;4(10):1005-1010. doi: 10.1021/ml400312j. Epub 2013 Sep 3. ACS Med Chem Lett. 2013. PMID: 24454993 Free PMC article.
O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis.
Schimpl M, Zheng X, Borodkin VS, Blair DE, Ferenbach AT, Schüttelkopf AW, Navratilova I, Aristotelous T, Albarbarawi O, Robinson DA, Macnaughtan MA, van Aalten DM. Schimpl M, et al. Among authors: aristotelous t. Nat Chem Biol. 2012 Dec;8(12):969-74. doi: 10.1038/nchembio.1108. Epub 2012 Oct 28. Nat Chem Biol. 2012. PMID: 23103942 Free PMC article.